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• W2040642210 abstract "Pyridazinone 1 was recently reported as a potent H3R antagonist with good drug-like properties and in vivo activity. A series of constrained amine analogs of 1 was synthesized to identify compounds with improved pharmacokinetic profiles. From these efforts, a new class of (S)-2-pyrrolidin-1-ylmethyl-1-pyrrolidinyl amides was identified." @default.
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• W2040642210 date "2011-09-01" @default.
• W2040642210 modified "2023-09-26" @default.
• W2040642210 title "Amine-constrained pyridazinone histamine H3 receptor antagonists" @default.
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• W2040642210 doi "https://doi.org/10.1016/j.bmcl.2011.06.094" @default.
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