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- W2040642697 abstract "The transition from acute to chronic pain states might be the most important challenge in research to improve clinical treatment of debilitating pain. We describe a recently identified mechanism of neuronal plasticity in primary afferent nociceptive nerve fibers (nociceptors) by which an acute inflammatory insult or environmental stressor can trigger long-lasting hypersensitivity of nociceptors to inflammatory cytokines. This phenomenon, hyperalgesic priming, depends on the epsilon isoform of protein kinase C (PKCepsilon) and a switch in intracellular signaling pathways that mediate cytokine-induced nociceptor hyperexcitability. We discuss the impact of this discovery on our understanding of, and ultimately our ability to treat, a variety of enigmatic and debilitating pain conditions, including those associated with repetitive injury, and generalized pain conditions, such as fibromyalgia." @default.
- W2040642697 created "2016-06-24" @default.
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- W2040642697 date "2009-12-01" @default.
- W2040642697 modified "2023-10-01" @default.
- W2040642697 title "Critical role of nociceptor plasticity in chronic pain" @default.
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- W2040642697 doi "https://doi.org/10.1016/j.tins.2009.07.007" @default.
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