FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040648721> ?p ?o ?g. }

• W2040648721 endingPage "6296" @default.
• W2040648721 startingPage "6279" @default.
• W2040648721 abstract "Chains of magnetosomes extracted from AMB-1 magnetotactic bacteria are shown to be highly efficient for cancer therapy when they are exposed to an alternative magnetic field. When a suspension containing MDA-MB-231 breast cancer cells was incubated in the presence of various amounts of extracted chains of magnetosomes, the viability of these cells remained high in the absence of an alternative magnetic field. By contrast, when this suspension was exposed to an alternative magnetic field of frequency 183 kHz and field strengths of 20, 40, or 60 mT, up to 100% of these cells were destroyed. The antitumoral activity of the extracted chains of magnetosomes is demonstrated further by showing that they can be used to fully eradicate a tumor xenografted under the skin of a mouse. For that, a suspension containing ∼1 mg of extracted chains of magnetosomes was administered within the tumor and the mouse was exposed to three heat cycles of 20 min, during which the tumor temperature was raised to ∼43 °C. We also demonstrate the higher efficiency of the extracted chains of magnetosomes compared with various other materials, i.e., whole inactive magnetotactic bacteria, individual magnetosomes not organized in chains, and two different types of chemically synthesized superparamagnetic iron oxide nanoparticles currently tested for alternative magnetic field cancer therapy. The higher efficiency of the extracted chains of magnetosomes compared with that of the other nanoparticles is attributed to three factors: (i) a specific absorption rate higher for the magnetosomes than for the chemically synthesized superparamagnetic iron oxide nanoparticles, (ii) a more uniform heating for the chains of magnetosomes than for the individual magnetosomes and (iii) the ability of the chains of magnetosomes to penetrate within the cancer cells or bind at the cell membrane following the application of the alternative magnetic field, which enables efficient cell destruction. Biodistribution studies revealed that extracted chains of magnetosomes administered directly within xenografted breast tumors progressively left the tumors during the 14 days following their administration and were then eliminated in large proportion in the feces." @default.
• W2040648721 created "2016-06-24" @default.
• W2040648721 creator A5013770987 @default.
• W2040648721 creator A5024198145 @default.
• W2040648721 creator A5051001306 @default.
• W2040648721 creator A5061083313 @default.
• W2040648721 creator A5069714472 @default.
• W2040648721 date "2011-07-14" @default.
• W2040648721 modified "2023-10-10" @default.
• W2040648721 title "Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy" @default.
• W2040648721 cites W1964462535 @default.
• W2040648721 cites W1972036558 @default.
• W2040648721 cites W1976728316 @default.
• W2040648721 cites W1976797458 @default.
• W2040648721 cites W1980365520 @default.
• W2040648721 cites W1996280453 @default.
• W2040648721 cites W2015371492 @default.
• W2040648721 cites W2023631656 @default.
• W2040648721 cites W2036670812 @default.
• W2040648721 cites W2041991782 @default.
• W2040648721 cites W2048378855 @default.
• W2040648721 cites W2049789508 @default.
• W2040648721 cites W2053604760 @default.
• W2040648721 cites W2066278514 @default.
• W2040648721 cites W2084374614 @default.
• W2040648721 cites W2086328136 @default.
• W2040648721 cites W2087959159 @default.
• W2040648721 cites W2093807603 @default.
• W2040648721 cites W2101111865 @default.
• W2040648721 cites W2104170190 @default.
• W2040648721 cites W2109322201 @default.
• W2040648721 cites W2112732159 @default.
• W2040648721 cites W2114107793 @default.
• W2040648721 cites W2114918609 @default.
• W2040648721 cites W2115604876 @default.
• W2040648721 cites W2119802846 @default.
• W2040648721 cites W2138765717 @default.
• W2040648721 cites W2138786741 @default.
• W2040648721 cites W2163893690 @default.
• W2040648721 cites W2164557053 @default.
• W2040648721 cites W2313223284 @default.
• W2040648721 cites W2320526032 @default.
• W2040648721 doi "https://doi.org/10.1021/nn201290k" @default.
• W2040648721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21732678" @default.
• W2040648721 hasPublicationYear "2011" @default.
• W2040648721 type Work @default.
• W2040648721 sameAs 2040648721 @default.
• W2040648721 citedByCount "259" @default.
• W2040648721 countsByYear W20406487212012 @default.
• W2040648721 countsByYear W20406487212013 @default.
• W2040648721 countsByYear W20406487212014 @default.
• W2040648721 countsByYear W20406487212015 @default.
• W2040648721 countsByYear W20406487212016 @default.
• W2040648721 countsByYear W20406487212017 @default.
• W2040648721 countsByYear W20406487212018 @default.
• W2040648721 countsByYear W20406487212019 @default.
• W2040648721 countsByYear W20406487212020 @default.
• W2040648721 countsByYear W20406487212021 @default.
• W2040648721 countsByYear W20406487212022 @default.
• W2040648721 countsByYear W20406487212023 @default.
• W2040648721 crossrefType "journal-article" @default.
• W2040648721 hasAuthorship W2040648721A5013770987 @default.
• W2040648721 hasAuthorship W2040648721A5024198145 @default.
• W2040648721 hasAuthorship W2040648721A5051001306 @default.
• W2040648721 hasAuthorship W2040648721A5061083313 @default.
• W2040648721 hasAuthorship W2040648721A5069714472 @default.
• W2040648721 hasConcept C105341887 @default.
• W2040648721 hasConcept C115260700 @default.
• W2040648721 hasConcept C121332964 @default.
• W2040648721 hasConcept C12554922 @default.
• W2040648721 hasConcept C127413603 @default.
• W2040648721 hasConcept C155672457 @default.
• W2040648721 hasConcept C171250308 @default.
• W2040648721 hasConcept C174626541 @default.
• W2040648721 hasConcept C185592680 @default.
• W2040648721 hasConcept C191897082 @default.
• W2040648721 hasConcept C192562407 @default.
• W2040648721 hasConcept C202444582 @default.
• W2040648721 hasConcept C23792430 @default.
• W2040648721 hasConcept C2777149353 @default.
• W2040648721 hasConcept C2777781897 @default.
• W2040648721 hasConcept C2778889443 @default.
• W2040648721 hasConcept C32546565 @default.
• W2040648721 hasConcept C33923547 @default.
• W2040648721 hasConcept C42360764 @default.
• W2040648721 hasConcept C5961521 @default.
• W2040648721 hasConcept C62520636 @default.
• W2040648721 hasConcept C86803240 @default.
• W2040648721 hasConcept C87023908 @default.
• W2040648721 hasConceptScore W2040648721C105341887 @default.
• W2040648721 hasConceptScore W2040648721C115260700 @default.
• W2040648721 hasConceptScore W2040648721C121332964 @default.
• W2040648721 hasConceptScore W2040648721C12554922 @default.
• W2040648721 hasConceptScore W2040648721C127413603 @default.
• W2040648721 hasConceptScore W2040648721C155672457 @default.
• W2040648721 hasConceptScore W2040648721C171250308 @default.
• W2040648721 hasConceptScore W2040648721C174626541 @default.
• W2040648721 hasConceptScore W2040648721C185592680 @default.

• next