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• W2040653264 endingPage "138" @default.
• W2040653264 startingPage "133" @default.
• W2040653264 abstract "We report 13C NMR measurements of the flux through aldose reductase in isolated rat sciatic nerve, and its inhibition by an aldose reductase inhibitor of the sulphonylnitromethane class. [1-13C] galactose was used as substrate, and the rate of production of [1-13C] dulcitol was measured. Quantitation required the use both of internal extracellular, and external, standards. The mean net forward flux (±S.D) was 20±11 nmol/(mL nerve water)/min (n = 10). In the presence of the inhibitor, flux was reduced significantly (p<0.001) to 13% of control. Since dulcitol is symmetrical, an estimate of the backward flux, to [6-13C] galactose, is also possible; under our conditions, this was negligible." @default.
• W2040653264 created "2016-06-24" @default.
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• W2040653264 date "1995-05-01" @default.
• W2040653264 modified "2023-09-25" @default.
• W2040653264 title "Inhibition of aldose reductase:13C NMR studies in isolated peripheral nerve" @default.
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• W2040653264 doi "https://doi.org/10.1002/nbm.1940080309" @default.
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