Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040653604> ?p ?o ?g. }
- W2040653604 endingPage "822" @default.
- W2040653604 startingPage "809" @default.
- W2040653604 abstract "Axons and Schwann cells exist in a highly interdependent relationship: damage to one cell type invariably leads to pathophysiological changes in the other. Greater understanding of communication between these cell types will not only give insight into peripheral nerve development, but also the reaction to and recovery from peripheral nerve injury. The type III isoform of neuregulin-1 (NRG1) has emerged as a key signaling factor that is expressed on axons and, through binding to erbB2/3 receptors on Schwann cells, regulates multiple phases of their development. In adulthood, NRG1 is dispensable for the maintenance of the myelin sheath; however, this factor is required for both axon regeneration and remyelination following nerve injury. The outcome of NRG1 signaling depends on interactions with other pathways within Schwann cells such as Notch, integrin and cAMP signaling. In certain circumstances, this signaling pathway may be maladaptive; for instance, direct binding of Mycobacterium leprae onto erbB2 receptors produces excessive activation and can actually promote demyelination. Attempts to modulate this pathway in order to promote nerve repair will therefore need to give consideration to the exact isoform used, as well as how it is processed and the context in which it is presented to the Schwann cell." @default.
- W2040653604 created "2016-06-24" @default.
- W2040653604 creator A5010154720 @default.
- W2040653604 creator A5037697439 @default.
- W2040653604 date "2011-11-01" @default.
- W2040653604 modified "2023-09-26" @default.
- W2040653604 title "The role of neuregulin-1 in the response to nerve injury" @default.
- W2040653604 cites W1515977320 @default.
- W2040653604 cites W1604121661 @default.
- W2040653604 cites W1646754425 @default.
- W2040653604 cites W1665419471 @default.
- W2040653604 cites W1956061739 @default.
- W2040653604 cites W1964321121 @default.
- W2040653604 cites W1964617439 @default.
- W2040653604 cites W1967919321 @default.
- W2040653604 cites W1970446746 @default.
- W2040653604 cites W1970796628 @default.
- W2040653604 cites W1972744392 @default.
- W2040653604 cites W1973188134 @default.
- W2040653604 cites W1973409138 @default.
- W2040653604 cites W1973976893 @default.
- W2040653604 cites W1976731473 @default.
- W2040653604 cites W1977068084 @default.
- W2040653604 cites W1977688919 @default.
- W2040653604 cites W1977893632 @default.
- W2040653604 cites W1978439333 @default.
- W2040653604 cites W1980141913 @default.
- W2040653604 cites W1982210988 @default.
- W2040653604 cites W1985825265 @default.
- W2040653604 cites W1988901915 @default.
- W2040653604 cites W1989453114 @default.
- W2040653604 cites W1990654868 @default.
- W2040653604 cites W1995191245 @default.
- W2040653604 cites W1995841153 @default.
- W2040653604 cites W1997914540 @default.
- W2040653604 cites W1998121393 @default.
- W2040653604 cites W1998279268 @default.
- W2040653604 cites W2000129128 @default.
- W2040653604 cites W2000953663 @default.
- W2040653604 cites W2002548290 @default.
- W2040653604 cites W2006409416 @default.
- W2040653604 cites W2012928993 @default.
- W2040653604 cites W2016449040 @default.
- W2040653604 cites W2016717347 @default.
- W2040653604 cites W2022084199 @default.
- W2040653604 cites W2022787088 @default.
- W2040653604 cites W2023469980 @default.
- W2040653604 cites W2024470896 @default.
- W2040653604 cites W2027364587 @default.
- W2040653604 cites W2028895530 @default.
- W2040653604 cites W2029416405 @default.
- W2040653604 cites W2030611592 @default.
- W2040653604 cites W2030860399 @default.
- W2040653604 cites W2035074539 @default.
- W2040653604 cites W2035551042 @default.
- W2040653604 cites W2039055179 @default.
- W2040653604 cites W2040508571 @default.
- W2040653604 cites W2041038752 @default.
- W2040653604 cites W2042190017 @default.
- W2040653604 cites W2043345702 @default.
- W2040653604 cites W2043471865 @default.
- W2040653604 cites W2057158750 @default.
- W2040653604 cites W2064209588 @default.
- W2040653604 cites W2067281779 @default.
- W2040653604 cites W2068059177 @default.
- W2040653604 cites W2068488653 @default.
- W2040653604 cites W2070347840 @default.
- W2040653604 cites W2070423416 @default.
- W2040653604 cites W2072677891 @default.
- W2040653604 cites W2075935381 @default.
- W2040653604 cites W2083649624 @default.
- W2040653604 cites W2085185404 @default.
- W2040653604 cites W2085494041 @default.
- W2040653604 cites W2086441579 @default.
- W2040653604 cites W2087065964 @default.
- W2040653604 cites W2091439778 @default.
- W2040653604 cites W2092000566 @default.
- W2040653604 cites W2092322285 @default.
- W2040653604 cites W2095257931 @default.
- W2040653604 cites W2095319772 @default.
- W2040653604 cites W2099882112 @default.
- W2040653604 cites W2101240671 @default.
- W2040653604 cites W2101697605 @default.
- W2040653604 cites W2102350231 @default.
- W2040653604 cites W2102718676 @default.
- W2040653604 cites W2107078481 @default.
- W2040653604 cites W2111731547 @default.
- W2040653604 cites W2113404473 @default.
- W2040653604 cites W2114648573 @default.
- W2040653604 cites W2115940913 @default.
- W2040653604 cites W2117387977 @default.
- W2040653604 cites W2118145481 @default.
- W2040653604 cites W2118156146 @default.
- W2040653604 cites W2120442017 @default.
- W2040653604 cites W2121801466 @default.
- W2040653604 cites W2121904301 @default.
- W2040653604 cites W2123819262 @default.
- W2040653604 cites W2126943028 @default.