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- W2040654118 abstract "The published work on pericardial function is reviewed briefly, emphasizing experiments designed to show whether or not the normal pericardium restrains cardiac volume. Recent work from this laboratory has shown that nitroprusside infusion in hypervolemic dogs with an intact pericardium shifts the whole of the ventricular diastolic pressure-volume or dimension curve downward (less pressure for a given volume). After pericardiectomy, nitroprusside shifts the pressure-volume or dimension relation along a single curve. These studies indicate that the pericardium exerts a restraining influence on the left ventricle and that it greatly modifies the response of the left ventricle to altered preload. Recent studies from other laboratories have demonstrated that the pericardium plays a major role in the dynamic interaction between the ventricles. Recent hemodynamic studies have shown that cardiac tamponade in patients with intrinsically elevated left ventricular diastolic pressure causes equilibration between right (but not left) ventricular diastolic pressure and pericardial pressure. Pulsus paradoxus is not found in these patients because resistance to left ventricular filling is constant throughout the respiratory cycle. Other recent hemodynamic work includes the description of occult constrictive pericardial disease and a report that effusive-constrictive pericarditis is common in neoplastic involvement of the heart and pericardium. The spectrum of infectious pericarditis is changing; the entity still poses difficult therapeutic questions. The proper treatment of uremic pericarditis, especially with tamponade, remains highly controversial. The relative places of increased dialysis, intrapericardial poorly absorbed corticosteroids, pericardiocentesis, pericardial window and pericardiectomy are yet to be determined." @default.
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- W2040654118 date "1978-12-01" @default.
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- W2040654118 title "The pericardium: An essay on some recent developments" @default.
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- W2040654118 doi "https://doi.org/10.1016/0002-9149(78)90692-6" @default.
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