FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040654890> ?p ?o ?g. }

• W2040654890 endingPage "446" @default.
• W2040654890 startingPage "439" @default.
• W2040654890 abstract "Aims: Patients with type 2 diabetes mellitus exhibit considerable platelet dysfunction, though this is poorly characterized in patients with diabetes taking aspirin for the primary prevention of cardiovascular events. We sought to compare platelet function in this patient population with that of a high-risk group of non-diabetic subjects with a history of previous myocardial infarction (MI), and to assess whether glycaemic control impacts on platelet function.Methods: Platelet aggregation was measured in response to incremental concentrations of five platelet agonists using light transmission aggregometry. All patients were taking aspirin, and aspirin insensitivity was defined as ≥20% arachidonic acid (AA) mediated aggregation. Patients with diabetes were divided according to glycaemic control (HbA1c): optimal ≤6.5, good 6.6–7.4 and suboptimal ≥7.5%.Results: In total, 85 patients with type 2 diabetes and 35 non-diabetic patients with previous MI were recruited. Compared to MI patients, diabetes patients had increased aggregation in response to multiple concentrations of epinephrine, collagen, adenosine diphosphate and AA. Aspirin insensitivity was more common in type 2 diabetes (15% vs. 0%, p = 0.037). Platelet aggregation was increased in response to several agonists patients with suboptimal glycaemic control compared to patients with optimal control. Aspirin insensitivity was also more common in patients with suboptimal glycaemic control compared to those with good or optimal control (26.0% vs. 8.3% vs. 4%, p = 0.04).Conclusion: Patients with type 2 diabetes mellitus, without proven vascular disease, exhibit platelet dysfunction and have increased platelet aggregation and aspirin insensitivity compared to non-diabetic patients with previous MI. Platelet dysfunction in diabetes is more severe in patients with suboptimal glycaemic control." @default.
• W2040654890 created "2016-06-24" @default.
• W2040654890 creator A5026330260 @default.
• W2040654890 creator A5028107472 @default.
• W2040654890 creator A5053436180 @default.
• W2040654890 creator A5058650782 @default.
• W2040654890 creator A5060565487 @default.
• W2040654890 creator A5069457785 @default.
• W2040654890 creator A5070137994 @default.
• W2040654890 creator A5070928555 @default.
• W2040654890 creator A5073551828 @default.
• W2040654890 creator A5075664480 @default.
• W2040654890 creator A5091318599 @default.
• W2040654890 date "2011-12-13" @default.
• W2040654890 modified "2023-10-17" @default.
• W2040654890 title "Platelet reactivity in type 2 diabetes mellitus: A comparative analysis with survivors of myocardial infarction and the role of glycaemic control" @default.
• W2040654890 cites W1553292321 @default.
• W2040654890 cites W1586781424 @default.
• W2040654890 cites W1964192560 @default.
• W2040654890 cites W1966562996 @default.
• W2040654890 cites W1967639757 @default.
• W2040654890 cites W1972571079 @default.
• W2040654890 cites W1985142448 @default.
• W2040654890 cites W1986971270 @default.
• W2040654890 cites W2001452537 @default.
• W2040654890 cites W2014759828 @default.
• W2040654890 cites W2034942998 @default.
• W2040654890 cites W2044615835 @default.
• W2040654890 cites W2045872180 @default.
• W2040654890 cites W2046664111 @default.
• W2040654890 cites W2050820265 @default.
• W2040654890 cites W2053286973 @default.
• W2040654890 cites W2068412092 @default.
• W2040654890 cites W2070687022 @default.
• W2040654890 cites W2079211463 @default.
• W2040654890 cites W2090978392 @default.
• W2040654890 cites W2096531477 @default.
• W2040654890 cites W2104599604 @default.
• W2040654890 cites W2104969665 @default.
• W2040654890 cites W2107410629 @default.
• W2040654890 cites W2131479667 @default.
• W2040654890 cites W2161043271 @default.
• W2040654890 cites W2170902262 @default.
• W2040654890 cites W2171294019 @default.
• W2040654890 cites W2180664789 @default.
• W2040654890 cites W2331274940 @default.
• W2040654890 cites W4213018424 @default.
• W2040654890 doi "https://doi.org/10.3109/09537104.2011.634932" @default.
• W2040654890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22150374" @default.
• W2040654890 hasPublicationYear "2011" @default.
• W2040654890 type Work @default.
• W2040654890 sameAs 2040654890 @default.
• W2040654890 citedByCount "25" @default.
• W2040654890 countsByYear W20406548902012 @default.
• W2040654890 countsByYear W20406548902014 @default.
• W2040654890 countsByYear W20406548902015 @default.
• W2040654890 countsByYear W20406548902016 @default.
• W2040654890 countsByYear W20406548902017 @default.
• W2040654890 countsByYear W20406548902018 @default.
• W2040654890 countsByYear W20406548902019 @default.
• W2040654890 countsByYear W20406548902020 @default.
• W2040654890 countsByYear W20406548902021 @default.
• W2040654890 countsByYear W20406548902022 @default.
• W2040654890 countsByYear W20406548902023 @default.
• W2040654890 crossrefType "journal-article" @default.
• W2040654890 hasAuthorship W2040654890A5026330260 @default.
• W2040654890 hasAuthorship W2040654890A5028107472 @default.
• W2040654890 hasAuthorship W2040654890A5053436180 @default.
• W2040654890 hasAuthorship W2040654890A5058650782 @default.
• W2040654890 hasAuthorship W2040654890A5060565487 @default.
• W2040654890 hasAuthorship W2040654890A5069457785 @default.
• W2040654890 hasAuthorship W2040654890A5070137994 @default.
• W2040654890 hasAuthorship W2040654890A5070928555 @default.
• W2040654890 hasAuthorship W2040654890A5073551828 @default.
• W2040654890 hasAuthorship W2040654890A5075664480 @default.
• W2040654890 hasAuthorship W2040654890A5091318599 @default.
• W2040654890 hasConcept C126322002 @default.
• W2040654890 hasConcept C134018914 @default.
• W2040654890 hasConcept C164705383 @default.
• W2040654890 hasConcept C181199279 @default.
• W2040654890 hasConcept C185592680 @default.
• W2040654890 hasConcept C2775859304 @default.
• W2040654890 hasConcept C2777180221 @default.
• W2040654890 hasConcept C2777628954 @default.
• W2040654890 hasConcept C2778078955 @default.
• W2040654890 hasConcept C2781232474 @default.
• W2040654890 hasConcept C2908647359 @default.
• W2040654890 hasConcept C2910068830 @default.
• W2040654890 hasConcept C500558357 @default.
• W2040654890 hasConcept C55493867 @default.
• W2040654890 hasConcept C555293320 @default.
• W2040654890 hasConcept C71924100 @default.
• W2040654890 hasConcept C89560881 @default.
• W2040654890 hasConcept C90924648 @default.
• W2040654890 hasConcept C99454951 @default.
• W2040654890 hasConceptScore W2040654890C126322002 @default.
• W2040654890 hasConceptScore W2040654890C134018914 @default.
• W2040654890 hasConceptScore W2040654890C164705383 @default.

• next