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- W2040659239 abstract "Cardiolipin (CL) is an anionic phospholipid with a dimeric structure predominantly localized in the mitochondrial inner membrane, where it is closely associated with mitochondrial function, biogenesis, and genome stability ( Daum, 1985 ; Janitor and Subik, 1993 ; Jiang et al., 2000 ; Schlame et al., 2000 ; Zhong et al., 2004 ). Previous studies have shown that yeast mutant cells lacking CL due to a disruption in CRD1, the structural gene encoding CL synthase, exhibit defective colony formation at elevated temperature even on glucose medium ( Jiang et al., 1999 ; Zhong et al., 2004 ), suggesting a role for CL in cellular processes apart from mitochondrial bioenergetics. In the current study, we present evidence that the crd1Δ mutant exhibits severe vacuolar defects, including swollen vacuole morphology and loss of vacuolar acidification, at 37°C. Moreover, vacuoles from crd1Δ show decreased vacuolar H + -ATPase activity and proton pumping, which may contribute to loss of vacuolar acidification. Deletion mutants in RTG2 and NHX1, which mediate vacuolar pH and ion homeostasis, rescue the defective colony formation phenotype of crd1Δ, strongly suggesting that the temperature sensitivity of crd1Δ is a consequence of the vacuolar defects. Our results demonstrate the existence of a novel mitochondria-vacuole signaling pathway mediated by CL synthesis." @default.
- W2040659239 created "2016-06-24" @default.
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- W2040659239 date "2008-12-01" @default.
- W2040659239 modified "2023-10-16" @default.
- W2040659239 title "Cardiolipin Mediates Cross-Talk between Mitochondria and the Vacuole" @default.
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- W2040659239 doi "https://doi.org/10.1091/mbc.e08-05-0486" @default.
- W2040659239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2592637" @default.
- W2040659239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18799619" @default.
- W2040659239 hasPublicationYear "2008" @default.
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