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- W2040659983 abstract "Two proteins (S1, S2) which stimulate cell growth in cultures of embryonic rat fibroblasts, have been isolated from fetal calf serum. S1 is a protein complex consisting of an α2-macroglobulin and insulin, asc ould be shown by immunological methods. For growth-activating activity both components are essential; when added separately to the cultures, they are ineffective. S2 has a molecular weight of about 26 000 D and does not cross-react with S1 in immunological tests. For optimal stimulation of the cultures both factors must be present together in the medium. As demonstrated by autoradiographic studies, there probably exist two different cell populations in the rat fibroblast cultures which either respond to S1 or S2. S1 and S2 strongly influence the metabolism of isolated fat cells. S1 behaves like insulin; S2 stimulates glucose oxidation and lipogenesis, but, in contrast to insulin and non-suppressible insulin-like activity, also activates the adenylate cyclase in these cells." @default.
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- W2040659983 date "1973-08-01" @default.
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- W2040659983 title "Properties of two growth-stimulating proteins isolated from fetal calf serum" @default.
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- W2040659983 doi "https://doi.org/10.1016/0014-4827(73)90297-8" @default.
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