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- W2040660946 abstract "Thalidomide has been shown to be metabolized mainly to phthaloylisoglutamine and a fluorescent metabolite which is probably a derivative of 3-hydroxyphthalic acid. These metabolites have been found in human, rabbit and rat urine after dosing with thalidomide. Little of the drug is excreted unchanged. Phthaloylisoglutamine has been isolated from rabbit urine and characterized. This metabolite (400 mg/kg) has no depressant effect in rats. The brain and plasma of rats killed 30 min after thalidomide administration contained thalidomide but no metabolites. The sedative effect thus appears to be due to the drug itself and not phthaloylisoglutamine. This work was supported by a grant from the Distillers Company (Biochemicals) Limited." @default.
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- W2040660946 date "1962-07-01" @default.
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- W2040660946 title "Phthaloylisoglutamine, a metabolite of thalidomide" @default.
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- W2040660946 doi "https://doi.org/10.1016/0024-3205(62)90128-5" @default.
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