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- W2040661611 abstract "Experiments were performed in 18 paralysed, ventilated, decerebrate adult cats to characterise projections from the Kölliker-Fuse nucleus (KFN) to hypoglossal (HG) motoneurons. Efferent neural activity was recorded from the medial branch of both HG nerves, right recurrent laryngeal (RL) nerve, and C3 branch of the left phrenic nerve. Electrical stimulation (1 Hz, 1 msec pulse duration) of discrete areas within the KFN coordinates elicited a preferential, predominantly ipsilateral burst of HG action potentials with an average stimulus–response latency of 8 msec. Tonic stimulation (5–20 Hz) frequently produced considerable HG temporal summation and the appearance of phasic inspiratory HG activity. Injection of 40–100 nl kainic acid (6.37 mM) into the rostral pontine site with the lowest electrical threshold for HG activation elicited a prolonged tonic HG activation. Following kainate injection, the electrical stimulation threshold for HG excitation increased. Pressure injections of 5–100 nl of 2 mM N-methyl-d-aspartic acid (NMDA) and 2 mM (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrobromide (AMPA) into the KFN were associated with activation and/or suppression of HG motor output. The results indicate that HG motoneurons innervating protrusor tongue muscles receive a selective projection from the KFN that can be activated by glutamate receptors on KF neurons." @default.
- W2040661611 created "2016-06-24" @default.
- W2040661611 creator A5015817805 @default.
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- W2040661611 date "1999-09-01" @default.
- W2040661611 modified "2023-10-15" @default.
- W2040661611 title "Premotor input to hypoglossal motoneurons from Kölliker-Fuse neurons in decerebrate cats" @default.
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- W2040661611 doi "https://doi.org/10.1016/s0034-5687(99)00058-4" @default.
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