FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040669093> ?p ?o ?g. }

• W2040669093 endingPage "199" @default.
• W2040669093 startingPage "187" @default.
• W2040669093 abstract "In a previous study, we demonstrated a significant release of adenosine, inosine and hypoxanthine during hypoxia and subsequent reoxygenation. The present study was designed to determine whether or not exogenous adenosine, inosine and hypoxanthine are beneficial for the recovery of hypoxia-induced loss of cardiac contractile force. Hearts were perfused for 20 min under hypoxic conditions, followed by 45 min-perfusion under reoxygenated conditions, and changes in contractile force, resting tension and metabolic parameters of the perfused heart were examined. When either adenosine, inosine or hypoxanthine were exogenously infused during hypoxia at the rate of 3 mumol/min, remarkable recovery (61 to 68%) of cardiac contractile force was observed upon reoxygenation. The recovery was accompanied by a significant restoration of myocardial ATP (90 to 100%) and CP contents (80 to 86%), suggesting that exogenous metabolites are utilized for the restoration of myocardial ATP during reoxygenation, which may lead to a beneficial recovery of hypoxia-induced loss of cardiac contractile force upon reoxygenation. Infusion of exogenous metabolites also resulted in an almost complete inhibition of hypoxia- and reoxygenation-induced release of creatine phosphokinase from the perfused heart as well as a significant depression of hypoxia-induced calcium accumulation in the cardiac tissue. Since these phenomena are considered to represent increases in cell membrane permeability, protection of the myocardium against hypoxia- and reoxygenation-induced changes in cell membrane permeability may be an alternative mechanism for the beneficial effect of adenosine, inosine and hypoxanthine on the hypoxic myocardium." @default.
• W2040669093 created "2016-06-24" @default.
• W2040669093 creator A5009749245 @default.
• W2040669093 creator A5022765890 @default.
• W2040669093 creator A5086013221 @default.
• W2040669093 creator A5090943443 @default.
• W2040669093 date "1988-03-01" @default.
• W2040669093 modified "2023-10-16" @default.
• W2040669093 title "Adenine nucleotide metabolites are beneficial for recovery of cardiac contractile force after hypoxia" @default.
• W2040669093 cites W1427695666 @default.
• W2040669093 cites W1921432376 @default.
• W2040669093 cites W1964866990 @default.
• W2040669093 cites W1973772383 @default.
• W2040669093 cites W1995187283 @default.
• W2040669093 cites W2005792277 @default.
• W2040669093 cites W2015977730 @default.
• W2040669093 cites W2016822721 @default.
• W2040669093 cites W2026570765 @default.
• W2040669093 cites W2030655590 @default.
• W2040669093 cites W2030855199 @default.
• W2040669093 cites W2033990860 @default.
• W2040669093 cites W2034683799 @default.
• W2040669093 cites W2039517367 @default.
• W2040669093 cites W2047854896 @default.
• W2040669093 cites W2060865242 @default.
• W2040669093 cites W2094379315 @default.
• W2040669093 cites W2094785178 @default.
• W2040669093 cites W2097744068 @default.
• W2040669093 cites W2100931753 @default.
• W2040669093 cites W2108301473 @default.
• W2040669093 cites W2123088115 @default.
• W2040669093 cites W2125283361 @default.
• W2040669093 cites W2132795937 @default.
• W2040669093 cites W2139630933 @default.
• W2040669093 cites W2400402105 @default.
• W2040669093 cites W2409597019 @default.
• W2040669093 cites W2412137171 @default.
• W2040669093 cites W2414232020 @default.
• W2040669093 cites W2414912449 @default.
• W2040669093 cites W2435487642 @default.
• W2040669093 cites W2742789898 @default.
• W2040669093 doi "https://doi.org/10.1016/s0022-2828(88)80052-x" @default.
• W2040669093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3398053" @default.
• W2040669093 hasPublicationYear "1988" @default.
• W2040669093 type Work @default.
• W2040669093 sameAs 2040669093 @default.
• W2040669093 citedByCount "39" @default.
• W2040669093 countsByYear W20406690932012 @default.
• W2040669093 countsByYear W20406690932015 @default.
• W2040669093 countsByYear W20406690932020 @default.
• W2040669093 countsByYear W20406690932022 @default.
• W2040669093 crossrefType "journal-article" @default.
• W2040669093 hasAuthorship W2040669093A5009749245 @default.
• W2040669093 hasAuthorship W2040669093A5022765890 @default.
• W2040669093 hasAuthorship W2040669093A5086013221 @default.
• W2040669093 hasAuthorship W2040669093A5090943443 @default.
• W2040669093 hasConcept C104317684 @default.
• W2040669093 hasConcept C126322002 @default.
• W2040669093 hasConcept C134018914 @default.
• W2040669093 hasConcept C146957229 @default.
• W2040669093 hasConcept C178790620 @default.
• W2040669093 hasConcept C181199279 @default.
• W2040669093 hasConcept C185592680 @default.
• W2040669093 hasConcept C2776991684 @default.
• W2040669093 hasConcept C2777610669 @default.
• W2040669093 hasConcept C2781116151 @default.
• W2040669093 hasConcept C2994266630 @default.
• W2040669093 hasConcept C36880943 @default.
• W2040669093 hasConcept C512185932 @default.
• W2040669093 hasConcept C540031477 @default.
• W2040669093 hasConcept C55493867 @default.
• W2040669093 hasConcept C71924100 @default.
• W2040669093 hasConcept C7836513 @default.
• W2040669093 hasConcept C86803240 @default.
• W2040669093 hasConceptScore W2040669093C104317684 @default.
• W2040669093 hasConceptScore W2040669093C126322002 @default.
• W2040669093 hasConceptScore W2040669093C134018914 @default.
• W2040669093 hasConceptScore W2040669093C146957229 @default.
• W2040669093 hasConceptScore W2040669093C178790620 @default.
• W2040669093 hasConceptScore W2040669093C181199279 @default.
• W2040669093 hasConceptScore W2040669093C185592680 @default.
• W2040669093 hasConceptScore W2040669093C2776991684 @default.
• W2040669093 hasConceptScore W2040669093C2777610669 @default.
• W2040669093 hasConceptScore W2040669093C2781116151 @default.
• W2040669093 hasConceptScore W2040669093C2994266630 @default.
• W2040669093 hasConceptScore W2040669093C36880943 @default.
• W2040669093 hasConceptScore W2040669093C512185932 @default.
• W2040669093 hasConceptScore W2040669093C540031477 @default.
• W2040669093 hasConceptScore W2040669093C55493867 @default.
• W2040669093 hasConceptScore W2040669093C71924100 @default.
• W2040669093 hasConceptScore W2040669093C7836513 @default.
• W2040669093 hasConceptScore W2040669093C86803240 @default.
• W2040669093 hasIssue "3" @default.
• W2040669093 hasLocation W20406690931 @default.
• W2040669093 hasLocation W20406690932 @default.
• W2040669093 hasOpenAccess W2040669093 @default.
• W2040669093 hasPrimaryLocation W20406690931 @default.
• W2040669093 hasRelatedWork W1829913204 @default.

• next