FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040673113> ?p ?o ?g. }

• W2040673113 endingPage "697" @default.
• W2040673113 startingPage "685" @default.
• W2040673113 abstract "Microglia are often considered a type of tissue macrophages analogous Langerhans' cells, while dendritic cells (DC) can be generated in vitro from cultured microglia in the presence of GM-CSF. In this study, we show that TGF-beta 1, in the presence of GM-CSF, promoted the growth and differentiation of glial cell-derived dendritic cells (GC-DC). TGF-beta 1-driven GC-DC exhibited an immature state reflected by low CD11c expression, augmented endocytosis, and reduced antigen presentation. Expression of Fas was inhibited in GM-CSF+TGF-beta 1-supplemented cell cultures and may relate to a long life span of GC-DC treated with GM-CSF+TGF-beta 1. IL-10 and IL-12 mRNA on GC-DC was not affected upon exposure to GM-CSF alone or to GM-CSF+IFN-gamma, GM-CSF+IL-10 or GM-CSF+TGF-beta 1. In sharp contrast, TGF-beta 1, in the presence of GM-CSF, dramatically up-regulated the expression of TNF-alpha and TGF-beta 1 mRNA. These results demonstrate that TGF-beta 1 seems to play a crucial role in the differentiation, functional skewing, and cytokine profile of GC-DC. TGF-beta 1-driven GC-DC awaits further investigation to facilitate a better understanding of the glia-T cell dialog as well as the pathogenesis and immunotherapy of central nervous system inflammatory and degenerative diseases." @default.
• W2040673113 created "2016-06-24" @default.
• W2040673113 creator A5005914730 @default.
• W2040673113 creator A5045137608 @default.
• W2040673113 creator A5055352258 @default.
• W2040673113 date "2002-12-01" @default.
• W2040673113 modified "2023-10-01" @default.
• W2040673113 title "TGF-β1 synergizes with GM-CSF to promote the generation of glial cell-derived dendriform cells in vitro" @default.
• W2040673113 cites W1533029876 @default.
• W2040673113 cites W1548938800 @default.
• W2040673113 cites W1566117376 @default.
• W2040673113 cites W1583820761 @default.
• W2040673113 cites W1593600686 @default.
• W2040673113 cites W1928303171 @default.
• W2040673113 cites W1976397405 @default.
• W2040673113 cites W1976692354 @default.
• W2040673113 cites W1981110373 @default.
• W2040673113 cites W1982120546 @default.
• W2040673113 cites W1982675296 @default.
• W2040673113 cites W1990176415 @default.
• W2040673113 cites W1999425834 @default.
• W2040673113 cites W2011630305 @default.
• W2040673113 cites W2019842033 @default.
• W2040673113 cites W2025554920 @default.
• W2040673113 cites W2031817202 @default.
• W2040673113 cites W2038481383 @default.
• W2040673113 cites W2041466047 @default.
• W2040673113 cites W2050707975 @default.
• W2040673113 cites W2059473240 @default.
• W2040673113 cites W2061393519 @default.
• W2040673113 cites W2062107675 @default.
• W2040673113 cites W2066599974 @default.
• W2040673113 cites W2072140854 @default.
• W2040673113 cites W2086387065 @default.
• W2040673113 cites W2090848204 @default.
• W2040673113 cites W2097998083 @default.
• W2040673113 cites W2100446366 @default.
• W2040673113 cites W2111220263 @default.
• W2040673113 cites W2111837231 @default.
• W2040673113 cites W2112293616 @default.
• W2040673113 cites W2122639455 @default.
• W2040673113 cites W2131981600 @default.
• W2040673113 cites W2149703418 @default.
• W2040673113 cites W2158005433 @default.
• W2040673113 cites W2162648912 @default.
• W2040673113 cites W2177327503 @default.
• W2040673113 cites W2468669825 @default.
• W2040673113 doi "https://doi.org/10.1016/s0889-1591(02)00020-x" @default.
• W2040673113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12480499" @default.
• W2040673113 hasPublicationYear "2002" @default.
• W2040673113 type Work @default.
• W2040673113 sameAs 2040673113 @default.
• W2040673113 citedByCount "14" @default.
• W2040673113 countsByYear W20406731132013 @default.
• W2040673113 countsByYear W20406731132015 @default.
• W2040673113 countsByYear W20406731132021 @default.
• W2040673113 countsByYear W20406731132022 @default.
• W2040673113 crossrefType "journal-article" @default.
• W2040673113 hasAuthorship W2040673113A5005914730 @default.
• W2040673113 hasAuthorship W2040673113A5045137608 @default.
• W2040673113 hasAuthorship W2040673113A5055352258 @default.
• W2040673113 hasConcept C104317684 @default.
• W2040673113 hasConcept C111001777 @default.
• W2040673113 hasConcept C118131993 @default.
• W2040673113 hasConcept C127716648 @default.
• W2040673113 hasConcept C147483822 @default.
• W2040673113 hasConcept C199360897 @default.
• W2040673113 hasConcept C203014093 @default.
• W2040673113 hasConcept C2776090121 @default.
• W2040673113 hasConcept C2776174256 @default.
• W2040673113 hasConcept C2776914184 @default.
• W2040673113 hasConcept C2778170410 @default.
• W2040673113 hasConcept C2778229498 @default.
• W2040673113 hasConcept C2778690821 @default.
• W2040673113 hasConcept C2779830541 @default.
• W2040673113 hasConcept C2779919695 @default.
• W2040673113 hasConcept C2781101188 @default.
• W2040673113 hasConcept C41008148 @default.
• W2040673113 hasConcept C55493867 @default.
• W2040673113 hasConcept C83464605 @default.
• W2040673113 hasConcept C86803240 @default.
• W2040673113 hasConcept C8891405 @default.
• W2040673113 hasConcept C95444343 @default.
• W2040673113 hasConceptScore W2040673113C104317684 @default.
• W2040673113 hasConceptScore W2040673113C111001777 @default.
• W2040673113 hasConceptScore W2040673113C118131993 @default.
• W2040673113 hasConceptScore W2040673113C127716648 @default.
• W2040673113 hasConceptScore W2040673113C147483822 @default.
• W2040673113 hasConceptScore W2040673113C199360897 @default.
• W2040673113 hasConceptScore W2040673113C203014093 @default.
• W2040673113 hasConceptScore W2040673113C2776090121 @default.
• W2040673113 hasConceptScore W2040673113C2776174256 @default.
• W2040673113 hasConceptScore W2040673113C2776914184 @default.
• W2040673113 hasConceptScore W2040673113C2778170410 @default.
• W2040673113 hasConceptScore W2040673113C2778229498 @default.
• W2040673113 hasConceptScore W2040673113C2778690821 @default.
• W2040673113 hasConceptScore W2040673113C2779830541 @default.
• W2040673113 hasConceptScore W2040673113C2779919695 @default.

• next