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• W2040673952 abstract "Rats were trained to nose-poke for intracranial self-stimulation (SS) with electrodes unilaterally implanted in the medial entorhinal cortex. The acute effects of naloxone (NX; 0.1–10 mg/kg, IP) on a continuous reinforcement schedule were determined. Reductions in the self-stimulation rates occurred only at moderate doses (median of individual changes = −36% at 1 and 5 mg/kg), whereas the high dose (10 mg/kg) was ineffective. None of the doses influenced operant behavior. These results are consistent with the hypothesis that endogenous opioid-opiate receptor mechanisms play a modulatory role in SS reward. Considering that NX was administered systematically the action of the drug on reinforcement levels may be mediated by a site distinct from the locus of stimulation." @default.
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• W2040673952 date "1986-03-01" @default.
• W2040673952 modified "2023-09-27" @default.
• W2040673952 title "Opioid-receptor blockade reduces nose-poke self-stimulation derived from medial entorhinal cortex" @default.
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• W2040673952 doi "https://doi.org/10.1016/0091-3057(86)90538-1" @default.
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