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- W2040675082 abstract "This study examined if CF mutation heterozygosity is associated with diseases of gastrointestinal epithelial barrier function.Swedish registers identified 865 patients with a diagnosis of CF between 1968 and 2003 and matched with 8101 individuals without CF. Gastrointestinal disease risk was examined among 1534 biological parents and 1396 siblings of CF patients, compared with 15,526 parents and 15,542 siblings of individuals without CF.First-degree relatives of CF patients were not at lower risk of the gastrointestinal diseases, in contrast with a raised risk among CF patients.Heterozygosity for CF gene mutations does not protect against gastrointestinal diseases where impaired barrier function may be relevant." @default.
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- W2040675082 date "2010-07-01" @default.
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- W2040675082 title "Cystic fibrosis gene mutations and gastrointestinal diseases" @default.
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- W2040675082 doi "https://doi.org/10.1016/j.jcf.2010.03.010" @default.
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