FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040677008> ?p ?o ?g. }

• W2040677008 endingPage "256" @default.
• W2040677008 startingPage "229" @default.
• W2040677008 abstract "Chaperonins are megadalton ring assemblies that mediate essential ATP-dependent assistance of protein folding to the native state in a variety of cellular compartments, including the mitochondrial matrix, the eukaryotic cytosol, and the bacterial cytoplasm. Structural studies of the bacterial chaperonin, GroEL, both alone and in complex with its co-chaperonin, GroES, have resolved the states of chaperonin that bind and fold non-native polypeptides. Functional studies have resolved the action of ATP binding and hydrolysis in driving the GroEL-GroES machine through its folding-active and binding-active states, respectively. Yet the exact fate of substrate polypeptide during these steps is only poorly understood. For example, while binding involves multivalent interactions between hydrophobic side-chains facing the central cavity of GroEL and exposed hydrophobic surfaces of the non-native protein, the structure of any polypeptide substrate while bound to GroEL remains unknown. It is also unclear whether binding to an open GroEL ring is accompanied by structural changes in the non-native substrate, in particular whether there is an unfolding action. As a polypeptide-bound ring becomes associated with GroES, do the large rigid-body movements of the GroEL apical domains serve as another source of a potential unfolding action? Regarding the encapsulated folding-active state, how does the central cavity itself influence the folding trajectory of a substrate? Finally, how do GroEL and GroES serve, as recently recognized, to assist the folding of substrates too large to be encapsulated inside the machine? Here, such questions are addressed with the findings available to date, and means of further resolving the states of chaperonin-associated polypeptide are discussed." @default.
• W2040677008 created "2016-06-24" @default.
• W2040677008 creator A5013764496 @default.
• W2040677008 creator A5034561133 @default.
• W2040677008 date "2003-05-01" @default.
• W2040677008 modified "2023-10-14" @default.
• W2040677008 title "Chaperonin-mediated protein folding: fate of substrate polypeptide" @default.
• W2040677008 cites W1490851253 @default.
• W2040677008 cites W1495345086 @default.
• W2040677008 cites W1525481902 @default.
• W2040677008 cites W1533808701 @default.
• W2040677008 cites W1547873835 @default.
• W2040677008 cites W1583558880 @default.
• W2040677008 cites W1583825507 @default.
• W2040677008 cites W1595207694 @default.
• W2040677008 cites W1625860372 @default.
• W2040677008 cites W1646791064 @default.
• W2040677008 cites W1809320936 @default.
• W2040677008 cites W1876533241 @default.
• W2040677008 cites W1892996896 @default.
• W2040677008 cites W1963770237 @default.
• W2040677008 cites W1965255559 @default.
• W2040677008 cites W1966760093 @default.
• W2040677008 cites W1967204430 @default.
• W2040677008 cites W1967798309 @default.
• W2040677008 cites W1969577157 @default.
• W2040677008 cites W1974347829 @default.
• W2040677008 cites W1977245883 @default.
• W2040677008 cites W1980360022 @default.
• W2040677008 cites W1980473700 @default.
• W2040677008 cites W1984596455 @default.
• W2040677008 cites W1986918984 @default.
• W2040677008 cites W1989999739 @default.
• W2040677008 cites W1990634143 @default.
• W2040677008 cites W1996645786 @default.
• W2040677008 cites W1998960610 @default.
• W2040677008 cites W2000069699 @default.
• W2040677008 cites W2000363955 @default.
• W2040677008 cites W2001628717 @default.
• W2040677008 cites W2003080309 @default.
• W2040677008 cites W2005785655 @default.
• W2040677008 cites W2009254330 @default.
• W2040677008 cites W2014095962 @default.
• W2040677008 cites W2016135054 @default.
• W2040677008 cites W2018097430 @default.
• W2040677008 cites W2022796050 @default.
• W2040677008 cites W2027333021 @default.
• W2040677008 cites W2029871341 @default.
• W2040677008 cites W2032311486 @default.
• W2040677008 cites W2034045174 @default.
• W2040677008 cites W2035823967 @default.
• W2040677008 cites W2035998327 @default.
• W2040677008 cites W2036126658 @default.
• W2040677008 cites W2039486080 @default.
• W2040677008 cites W2041052616 @default.
• W2040677008 cites W2041505869 @default.
• W2040677008 cites W2042745916 @default.
• W2040677008 cites W2043824505 @default.
• W2040677008 cites W2045777307 @default.
• W2040677008 cites W2048076616 @default.
• W2040677008 cites W2048906768 @default.
• W2040677008 cites W2049713307 @default.
• W2040677008 cites W2053514414 @default.
• W2040677008 cites W2053855935 @default.
• W2040677008 cites W2058888270 @default.
• W2040677008 cites W2062267688 @default.
• W2040677008 cites W2070809545 @default.
• W2040677008 cites W2071064319 @default.
• W2040677008 cites W2071213863 @default.
• W2040677008 cites W2076250087 @default.
• W2040677008 cites W2076723876 @default.
• W2040677008 cites W2077492725 @default.
• W2040677008 cites W2078684251 @default.
• W2040677008 cites W2081422975 @default.
• W2040677008 cites W2082612432 @default.
• W2040677008 cites W2083765596 @default.
• W2040677008 cites W2087477235 @default.
• W2040677008 cites W2088780328 @default.
• W2040677008 cites W2088981849 @default.
• W2040677008 cites W2096966529 @default.
• W2040677008 cites W2098665638 @default.
• W2040677008 cites W2105799023 @default.
• W2040677008 cites W2127721047 @default.
• W2040677008 cites W2129214482 @default.
• W2040677008 cites W2132006420 @default.
• W2040677008 cites W2138749342 @default.
• W2040677008 cites W2142338805 @default.
• W2040677008 cites W2144263933 @default.
• W2040677008 cites W2145122280 @default.
• W2040677008 cites W2147281292 @default.
• W2040677008 cites W2147420240 @default.
• W2040677008 cites W2147739915 @default.
• W2040677008 cites W2163671005 @default.
• W2040677008 cites W2168117947 @default.
• W2040677008 cites W2169040359 @default.
• W2040677008 cites W94733720 @default.
• W2040677008 doi "https://doi.org/10.1017/s0033583503003883" @default.
• W2040677008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14686103" @default.

• next