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- W2040677595 endingPage "2484" @default.
- W2040677595 startingPage "2484" @default.
- W2040677595 abstract "The selective reaction of one functional group in the presence of others is not a trivial task. A noteworthy amount of research has been dedicated to the chemoselective reaction of the hydroxyl moiety. This group is prevalent in many biologically important molecules including natural products and proteins. However, targeting the hydroxyl group is difficult for many reasons including its relatively low nucleophilicity in comparison to other ubiquitous functional groups such as amines and thiols. Additionally, many of the developed chemoselective reactions cannot be used in the presence of water. Despite these complications, chemoselective transformation of the hydroxyl moiety has been utilized in the synthesis of complex natural product derivatives, the reaction of tyrosine residues in proteins, the isolation of natural products and is the mechanism of action of myriad drugs. Here, methods for selective targeting of this group, as well as applications of several devised methods, are described." @default.
- W2040677595 created "2016-06-24" @default.
- W2040677595 creator A5020668519 @default.
- W2040677595 creator A5023317651 @default.
- W2040677595 date "2012-01-01" @default.
- W2040677595 modified "2023-10-18" @default.
- W2040677595 title "Chemoselective hydroxyl group transformation: an elusive target" @default.
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- W2040677595 doi "https://doi.org/10.1039/c2mb25122a" @default.
- W2040677595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3430791" @default.
- W2040677595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22695722" @default.
- W2040677595 hasPublicationYear "2012" @default.
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