Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040677756> ?p ?o ?g. }
- W2040677756 endingPage "828" @default.
- W2040677756 startingPage "818" @default.
- W2040677756 abstract "ABSTRACT St. Louis encephalitis virus (SLEV) is a mosquito-borne flavivirus responsible for several human encephalitis outbreaks over the last 80 years. Mature flavivirus virions are coated with dimeric envelope (E) proteins that mediate attachment and fusion with host cells. E is a class II fusion protein, the hallmark of which is a distinct dimer-to-trimer rearrangement that occurs upon endosomal acidification and insertion of hydrophobic fusion peptides into the endosomal membrane. Herein, we report the crystal structure of SLEV E in the posfusion trimer conformation. The structure revealed specific features that differentiate SLEV E from trimers of related flavi- and alphaviruses. SLEV E fusion loops have distinct intermediate spacing such that they are positioned further apart than previously observed in flaviviruses but closer together than Semliki Forest virus, an alphavirus. Domains II and III (DII and DIII) of SLEV E also adopt different angles relative to DI, which suggests that the DI-DII joint may accommodate spheroidal motions. However, trimer interfaces are well conserved among flaviviruses, so it is likely the differences observed represent structural features specific to SLEV function. Analysis of surface potentials revealed a basic platform underneath flavivirus fusion loops that may interact with the anionic lipid head groups found in membranes. Taken together, these results highlight variations in E structure and assembly that may direct virus-specific interactions with host determinants to influence pathogenesis." @default.
- W2040677756 created "2016-06-24" @default.
- W2040677756 creator A5043369734 @default.
- W2040677756 creator A5060952990 @default.
- W2040677756 creator A5061136971 @default.
- W2040677756 date "2013-01-15" @default.
- W2040677756 modified "2023-10-01" @default.
- W2040677756 title "Structure of the St. Louis Encephalitis Virus Postfusion Envelope Trimer" @default.
- W2040677756 cites W1539796472 @default.
- W2040677756 cites W1599389506 @default.
- W2040677756 cites W1600966607 @default.
- W2040677756 cites W1622190752 @default.
- W2040677756 cites W1669786642 @default.
- W2040677756 cites W1766564474 @default.
- W2040677756 cites W1966763137 @default.
- W2040677756 cites W1968444714 @default.
- W2040677756 cites W1970455211 @default.
- W2040677756 cites W1985799231 @default.
- W2040677756 cites W1988421459 @default.
- W2040677756 cites W1990061195 @default.
- W2040677756 cites W1993001714 @default.
- W2040677756 cites W2001641653 @default.
- W2040677756 cites W2028155324 @default.
- W2040677756 cites W2029582401 @default.
- W2040677756 cites W2029869358 @default.
- W2040677756 cites W2034125106 @default.
- W2040677756 cites W2034887357 @default.
- W2040677756 cites W2035503835 @default.
- W2040677756 cites W2046254711 @default.
- W2040677756 cites W2047399603 @default.
- W2040677756 cites W2048728259 @default.
- W2040677756 cites W2050898334 @default.
- W2040677756 cites W2051976869 @default.
- W2040677756 cites W2060259273 @default.
- W2040677756 cites W2063657073 @default.
- W2040677756 cites W2068419533 @default.
- W2040677756 cites W2070524991 @default.
- W2040677756 cites W2072897393 @default.
- W2040677756 cites W2078194494 @default.
- W2040677756 cites W2080405903 @default.
- W2040677756 cites W2084993024 @default.
- W2040677756 cites W2086515925 @default.
- W2040677756 cites W2089521177 @default.
- W2040677756 cites W2092211067 @default.
- W2040677756 cites W2096025413 @default.
- W2040677756 cites W2096278221 @default.
- W2040677756 cites W2096398014 @default.
- W2040677756 cites W2099860386 @default.
- W2040677756 cites W2102264941 @default.
- W2040677756 cites W2102575242 @default.
- W2040677756 cites W2103714813 @default.
- W2040677756 cites W2104428288 @default.
- W2040677756 cites W2104718752 @default.
- W2040677756 cites W2109184569 @default.
- W2040677756 cites W2109993434 @default.
- W2040677756 cites W2111613780 @default.
- W2040677756 cites W2119489910 @default.
- W2040677756 cites W2120590343 @default.
- W2040677756 cites W2121726045 @default.
- W2040677756 cites W2123032625 @default.
- W2040677756 cites W2124010338 @default.
- W2040677756 cites W2124547357 @default.
- W2040677756 cites W2126241606 @default.
- W2040677756 cites W2130810814 @default.
- W2040677756 cites W2137015675 @default.
- W2040677756 cites W2137159492 @default.
- W2040677756 cites W2137983400 @default.
- W2040677756 cites W2137995709 @default.
- W2040677756 cites W2139450691 @default.
- W2040677756 cites W2140182479 @default.
- W2040677756 cites W2140255086 @default.
- W2040677756 cites W2140630012 @default.
- W2040677756 cites W2141349592 @default.
- W2040677756 cites W2141918346 @default.
- W2040677756 cites W2142445664 @default.
- W2040677756 cites W2142758749 @default.
- W2040677756 cites W2144081223 @default.
- W2040677756 cites W2144088993 @default.
- W2040677756 cites W2150516802 @default.
- W2040677756 cites W2161870238 @default.
- W2040677756 cites W2165006020 @default.
- W2040677756 cites W2165565773 @default.
- W2040677756 cites W2169886236 @default.
- W2040677756 cites W2399327277 @default.
- W2040677756 cites W2417193139 @default.
- W2040677756 doi "https://doi.org/10.1128/jvi.01950-12" @default.
- W2040677756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3554068" @default.
- W2040677756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23115296" @default.
- W2040677756 hasPublicationYear "2013" @default.
- W2040677756 type Work @default.
- W2040677756 sameAs 2040677756 @default.
- W2040677756 citedByCount "29" @default.
- W2040677756 countsByYear W20406777562013 @default.
- W2040677756 countsByYear W20406777562014 @default.
- W2040677756 countsByYear W20406777562016 @default.
- W2040677756 countsByYear W20406777562017 @default.
- W2040677756 countsByYear W20406777562018 @default.
- W2040677756 countsByYear W20406777562019 @default.