Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040688855> ?p ?o ?g. }
- W2040688855 endingPage "48" @default.
- W2040688855 startingPage "42" @default.
- W2040688855 abstract "Betacellulin was initially detected as a growth-promoting factor in the conditioned medium of a mouse pancreatic β-cell tumor cell line. Sequencing of the purified protein and of the cloned cDNA supported the assumption that betacellulin is a new ligand of the epidermal growth factor receptor (EGFR), which was later confirmed experimentally. As a typical EGFR ligand, betacellulin is expressed by a variety of cell types and tissues, and the soluble growth factor is proteolytically cleaved from a larger membrane-anchored precursor. Importantly, BTC can – in addition to the EGFR – bind and activate all possible heterodimeric combinations of the related ERBB receptors including the highly oncogenic ERBB2/3 dimer, as well as homodimers of ERBB4. While a large number of studies attest a role for betacellulin in the differentiation of pancreatic β-cells, the last decade witnessed the association of betacellulin with a large number of additional biological processes, ranging from reproduction to the control of neural stem cells." @default.
- W2040688855 created "2016-06-24" @default.
- W2040688855 creator A5023390854 @default.
- W2040688855 creator A5024292257 @default.
- W2040688855 creator A5029759771 @default.
- W2040688855 date "2014-04-01" @default.
- W2040688855 modified "2023-10-18" @default.
- W2040688855 title "The ABC of BTC: Structural properties and biological roles of betacellulin" @default.
- W2040688855 cites W139613233 @default.
- W2040688855 cites W1521352617 @default.
- W2040688855 cites W1536336415 @default.
- W2040688855 cites W1595575599 @default.
- W2040688855 cites W1965355187 @default.
- W2040688855 cites W1965630120 @default.
- W2040688855 cites W1971644781 @default.
- W2040688855 cites W1971917010 @default.
- W2040688855 cites W1975127503 @default.
- W2040688855 cites W1977511249 @default.
- W2040688855 cites W1980584021 @default.
- W2040688855 cites W1980865761 @default.
- W2040688855 cites W1981125688 @default.
- W2040688855 cites W1983334454 @default.
- W2040688855 cites W1986335023 @default.
- W2040688855 cites W1986375433 @default.
- W2040688855 cites W1988298829 @default.
- W2040688855 cites W1991888662 @default.
- W2040688855 cites W1992913621 @default.
- W2040688855 cites W1993045869 @default.
- W2040688855 cites W1993454969 @default.
- W2040688855 cites W1994532562 @default.
- W2040688855 cites W1997894998 @default.
- W2040688855 cites W2000749669 @default.
- W2040688855 cites W2006086550 @default.
- W2040688855 cites W2009658126 @default.
- W2040688855 cites W2017047335 @default.
- W2040688855 cites W2019013172 @default.
- W2040688855 cites W2019116727 @default.
- W2040688855 cites W2022406746 @default.
- W2040688855 cites W2023559232 @default.
- W2040688855 cites W2029918977 @default.
- W2040688855 cites W2031631150 @default.
- W2040688855 cites W2032552649 @default.
- W2040688855 cites W2034122106 @default.
- W2040688855 cites W2034614477 @default.
- W2040688855 cites W2035260089 @default.
- W2040688855 cites W2035284017 @default.
- W2040688855 cites W2038545140 @default.
- W2040688855 cites W2038936495 @default.
- W2040688855 cites W2042940659 @default.
- W2040688855 cites W2043313325 @default.
- W2040688855 cites W2047675510 @default.
- W2040688855 cites W2052868121 @default.
- W2040688855 cites W2054783675 @default.
- W2040688855 cites W2056881172 @default.
- W2040688855 cites W2058651442 @default.
- W2040688855 cites W2061651497 @default.
- W2040688855 cites W2063014729 @default.
- W2040688855 cites W2063376762 @default.
- W2040688855 cites W2066209685 @default.
- W2040688855 cites W2068122204 @default.
- W2040688855 cites W2068541071 @default.
- W2040688855 cites W2072219853 @default.
- W2040688855 cites W2072639918 @default.
- W2040688855 cites W2079556349 @default.
- W2040688855 cites W2079913429 @default.
- W2040688855 cites W2081741933 @default.
- W2040688855 cites W2082738785 @default.
- W2040688855 cites W2083051428 @default.
- W2040688855 cites W2084172300 @default.
- W2040688855 cites W2085382964 @default.
- W2040688855 cites W2086240498 @default.
- W2040688855 cites W2090732437 @default.
- W2040688855 cites W2091756351 @default.
- W2040688855 cites W2094118944 @default.
- W2040688855 cites W2094527303 @default.
- W2040688855 cites W2094540897 @default.
- W2040688855 cites W2099367586 @default.
- W2040688855 cites W2103809159 @default.
- W2040688855 cites W2103834956 @default.
- W2040688855 cites W2107535776 @default.
- W2040688855 cites W2114062215 @default.
- W2040688855 cites W2116979396 @default.
- W2040688855 cites W2117382642 @default.
- W2040688855 cites W2118029847 @default.
- W2040688855 cites W2121266425 @default.
- W2040688855 cites W2122089558 @default.
- W2040688855 cites W2126816487 @default.
- W2040688855 cites W2128959593 @default.
- W2040688855 cites W2129033989 @default.
- W2040688855 cites W2134889735 @default.
- W2040688855 cites W2135663646 @default.
- W2040688855 cites W2136459373 @default.
- W2040688855 cites W2139731895 @default.
- W2040688855 cites W2142272547 @default.
- W2040688855 cites W2143632427 @default.
- W2040688855 cites W2144191082 @default.
- W2040688855 cites W2151386694 @default.
- W2040688855 cites W2157824687 @default.