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- W2040690180 abstract "We describe the synthesis of a series of low molecular weight inhibitors of the alphavbeta3 integrin obtained by modifying a high-throughput screening hit with micromolar activity. A solid phase synthesis to prepare 3-phenylthio-3-nicotinyl propionic acid derivatives, exemplified by 13c, was set up. Compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit cell adhesion mediated by vitronectin have been obtained." @default.
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- W2040690180 date "2004-02-01" @default.
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- W2040690180 title "Solid-phase synthesis of a small library of 3-phenylthio-3-nicotinyl propionic acid derivatives acting as antagonists of the integrin αVβ3" @default.
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- W2040690180 doi "https://doi.org/10.1016/j.bmcl.2003.11.045" @default.
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