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- W2040691189 abstract "1. Using in vivo microdialysis, we studied the effects of apomorphine on the release of acetylcholine (ACh) in the striatum of freely-moving rats. 2. Basal release of ACh was 3.01 +/- 0.51 pmol/15 min in 30 microliters (containing of 10 microM neostigmine) of the striatal perfusate. 3. Ringer containing tetrodotoxin (1 microM), hemicholinium-3 (5 mM), or Ca(2+)-free Ringer was perfused into the striatum. Each of these treatments produced a significant attenuation in release content of ACh. High K+ (30 mM) produced a significant increase in ACh release. 4. In normal rats, apomorphine (0.05 mg/kg, s.c.) increased striatal ACh release. A high dose (1.0 mg/kg) significantly attenuated release. 5. In 6-OHDA-pretreated rats, although the lower dose of apomorphine did not increase striatal ACh release, the high dose produced a more significant attenuation of release. 6. It is concluded that apomorphine enhanced or attenuated the striatal ACh release and that this effect was regulated by nigro-striatal dopaminergic system in the freely moving rats." @default.
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- W2040691189 title "An investigation into the effects of apomorphine on the release of acetylcholine in the striatum of freely-moving rat using in vivo microdialysis" @default.
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- W2040691189 doi "https://doi.org/10.1016/0306-3623(93)90421-s" @default.
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