FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040691497> ?p ?o ?g. }

• W2040691497 endingPage "288" @default.
• W2040691497 startingPage "280" @default.
• W2040691497 abstract "Transfection of dendritic cells (DCs) with RNA was shown to be effective in the generation of antigen-specific T cells, probably due to the induction of a polyclonal T cell response directed against multiple antigens. To verify this assumption we used DCs, generated from cytomegalovirus (CMV)-negative or -positive donors, that were electroporated with in vitro-transcribed RNA (in vitro transcript, IVT) coding for the CMV pp65 antigen. We found that transfection of DCs with pp65 IVT induces an expansion of polyclonal CD8+ T lymphocytes that recognize peptide antigens presented on different HLA molecules. These T lymphocytes are able to lyse DCs pulsed with pp65-derived peptides or transfected with the cognate IVT. Furthermore, this approach allowed the identification of immunodominant epitopes presented upon IVT transfection. Interestingly, transfection of DCs with pp65 IVT resulted in the induction of CD4+-specific T cells. Cotransfection of DCs with IVTs coding for the CMV antigens pp65 and IE1 elicited polyclonal T lymphocytes specific for peptides derived from both antigens. More importantly, cytotoxic T cells could be generated in two of three CMV-negative donors. Finally, functional CMV-specific autologous cytotoxic T lymphocytes were successfully generated from immunosuppressed patients after allogeneic hematopoietic stem cell transplantation." @default.
• W2040691497 created "2016-06-24" @default.
• W2040691497 creator A5014277422 @default.
• W2040691497 creator A5027152672 @default.
• W2040691497 creator A5031749009 @default.
• W2040691497 creator A5033842343 @default.
• W2040691497 creator A5067607487 @default.
• W2040691497 creator A5073687210 @default.
• W2040691497 creator A5078112031 @default.
• W2040691497 creator A5085504780 @default.
• W2040691497 date "2006-02-01" @default.
• W2040691497 modified "2023-09-25" @default.
• W2040691497 title "Transfection of Dendritic Cells with in Vitro-Transcribed CMV RNA Induces Polyclonal CD8+- and CD4+-Mediated CMV-Specific T Cell Responses" @default.
• W2040691497 cites W1556976811 @default.
• W2040691497 cites W1568041502 @default.
• W2040691497 cites W1661544713 @default.
• W2040691497 cites W1977648435 @default.
• W2040691497 cites W1977812921 @default.
• W2040691497 cites W1982752226 @default.
• W2040691497 cites W1989550920 @default.
• W2040691497 cites W1997082378 @default.
• W2040691497 cites W2003979549 @default.
• W2040691497 cites W2008964614 @default.
• W2040691497 cites W2009607549 @default.
• W2040691497 cites W2019248811 @default.
• W2040691497 cites W2028092080 @default.
• W2040691497 cites W2038220267 @default.
• W2040691497 cites W2039635018 @default.
• W2040691497 cites W2042411369 @default.
• W2040691497 cites W2044349268 @default.
• W2040691497 cites W2046718813 @default.
• W2040691497 cites W2056316684 @default.
• W2040691497 cites W2058479453 @default.
• W2040691497 cites W2074073395 @default.
• W2040691497 cites W2087976898 @default.
• W2040691497 cites W2096309940 @default.
• W2040691497 cites W2103589467 @default.
• W2040691497 cites W2117062643 @default.
• W2040691497 cites W2119627739 @default.
• W2040691497 cites W2129537109 @default.
• W2040691497 cites W2143682490 @default.
• W2040691497 cites W2153194315 @default.
• W2040691497 cites W2154426926 @default.
• W2040691497 cites W2170240282 @default.
• W2040691497 cites W2315098267 @default.
• W2040691497 cites W2415234673 @default.
• W2040691497 doi "https://doi.org/10.1016/j.ymthe.2005.08.019" @default.
• W2040691497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16219490" @default.
• W2040691497 hasPublicationYear "2006" @default.
• W2040691497 type Work @default.
• W2040691497 sameAs 2040691497 @default.
• W2040691497 citedByCount "23" @default.
• W2040691497 countsByYear W20406914972012 @default.
• W2040691497 countsByYear W20406914972014 @default.
• W2040691497 countsByYear W20406914972017 @default.
• W2040691497 countsByYear W20406914972018 @default.
• W2040691497 countsByYear W20406914972021 @default.
• W2040691497 crossrefType "journal-article" @default.
• W2040691497 hasAuthorship W2040691497A5014277422 @default.
• W2040691497 hasAuthorship W2040691497A5027152672 @default.
• W2040691497 hasAuthorship W2040691497A5031749009 @default.
• W2040691497 hasAuthorship W2040691497A5033842343 @default.
• W2040691497 hasAuthorship W2040691497A5067607487 @default.
• W2040691497 hasAuthorship W2040691497A5073687210 @default.
• W2040691497 hasAuthorship W2040691497A5078112031 @default.
• W2040691497 hasAuthorship W2040691497A5085504780 @default.
• W2040691497 hasBestOaLocation W20406914971 @default.
• W2040691497 hasConcept C147483822 @default.
• W2040691497 hasConcept C153911025 @default.
• W2040691497 hasConcept C154317977 @default.
• W2040691497 hasConcept C159047783 @default.
• W2040691497 hasConcept C167672396 @default.
• W2040691497 hasConcept C195616568 @default.
• W2040691497 hasConcept C202751555 @default.
• W2040691497 hasConcept C203014093 @default.
• W2040691497 hasConcept C2776090121 @default.
• W2040691497 hasConcept C54009773 @default.
• W2040691497 hasConcept C54355233 @default.
• W2040691497 hasConcept C55493867 @default.
• W2040691497 hasConcept C67662055 @default.
• W2040691497 hasConcept C81885089 @default.
• W2040691497 hasConcept C86803240 @default.
• W2040691497 hasConcept C8891405 @default.
• W2040691497 hasConcept C956191 @default.
• W2040691497 hasConceptScore W2040691497C147483822 @default.
• W2040691497 hasConceptScore W2040691497C153911025 @default.
• W2040691497 hasConceptScore W2040691497C154317977 @default.
• W2040691497 hasConceptScore W2040691497C159047783 @default.
• W2040691497 hasConceptScore W2040691497C167672396 @default.
• W2040691497 hasConceptScore W2040691497C195616568 @default.
• W2040691497 hasConceptScore W2040691497C202751555 @default.
• W2040691497 hasConceptScore W2040691497C203014093 @default.
• W2040691497 hasConceptScore W2040691497C2776090121 @default.
• W2040691497 hasConceptScore W2040691497C54009773 @default.
• W2040691497 hasConceptScore W2040691497C54355233 @default.
• W2040691497 hasConceptScore W2040691497C55493867 @default.
• W2040691497 hasConceptScore W2040691497C67662055 @default.
• W2040691497 hasConceptScore W2040691497C81885089 @default.

• next