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- W2040694580 abstract "A low-intensity thermally evoked tail avoidance reflex (LITETAR) was used to study changes in nociceptive response produced by local anesthetics and cobalt chloride microinjected into the dorsal posterior mesencephalic tegmentum (DPMT) of conscious rats. Dose-related prolongation of the LITETAR (e.g., analgesia) was observed when lidocaine, cocaine, and bupivacaine were administered into the DPMT. Analgesic actions were also demonstrated when cobalt chloride was microinjected into the DPMT. The analgesic actions of these different neuronal suppressants provide support for the hypothesis that there exists tonic activity of hyperalgesic processes in the rat brain stem." @default.
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- W2040694580 date "1992-11-01" @default.
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- W2040694580 title "Analgesic actions of local anesthetics and cobalt chloride in the rat brain stem" @default.
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- W2040694580 doi "https://doi.org/10.1016/0091-3057(92)90426-g" @default.
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