FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040695574> ?p ?o ?g. }

• W2040695574 endingPage "989" @default.
• W2040695574 startingPage "978" @default.
• W2040695574 abstract "Pharmacological studies using bradykinin B2 receptor antagonists suggest that bradykinin, an early mediator of inflammation and the main metabolite of the kallikrein-kinin system, is involved in secondary brain damage after cerebral ischemia. However, the time-course of bradykinin production and kinin receptor expression as well as the conclusive role of bradykinin B2 receptors for brain damage after experimental stroke have not been elucidated so far. C57/Bl6 mice were subjected to 45 mins of middle cerebral artery occlusion (MCAO) and 2, 4, 8, 24, and 48 h later brains were removed for the analysis of tissue bradykinin concentration and kinin B2 receptor mRNA and protein expression. Brain edema, infarct volume, functional outcome, and long-term survival were assessed in WT and B2-/- mice 24 h or 7 days after MCAO. Tissue bradykinin was maximally increased 12 h after ischemia (three-fold), while kinin B2 receptor mRNA upregulation peaked 24 to 48 h after MCAO (10- to 12-fold versus naïve brain tissue). Immunohistochemistry revealed that kinin B2 receptors were constitutively and widely expressed in mouse brain, were upregulated 2 h after ischemia in cells showing signs of ischemic damage, and remained upregulated in the penumbra up to 24 h after ischemia. B2-/- mice had improved motor function (P<0.05), smaller infarct volumes (-38%; P<0.01), developed less brain edema (-87%; P<0.05), and survived longer (P<0.01) as compared with wild-type controls. The current results show that bradykinin is produced in the brain, kinin B2 receptors are upregulated on dying cells, and B2 receptors are involved in cell death and brain edema formation after experimental stroke." @default.
• W2040695574 created "2016-06-24" @default.
• W2040695574 creator A5003269288 @default.
• W2040695574 creator A5004569891 @default.
• W2040695574 creator A5015226179 @default.
• W2040695574 creator A5018202372 @default.
• W2040695574 creator A5030232036 @default.
• W2040695574 creator A5050370903 @default.
• W2040695574 creator A5066625527 @default.
• W2040695574 date "2005-04-06" @default.
• W2040695574 modified "2023-10-17" @default.
• W2040695574 title "Release of Bradykinin and Expression of Kinin B₂Receptors in the Brain: Role for Cell Death and Brain Edema Formation After Focal Cerebral Ischemia in Mice" @default.
• W2040695574 cites W104100394 @default.
• W2040695574 cites W1499948348 @default.
• W2040695574 cites W1541402103 @default.
• W2040695574 cites W1568178675 @default.
• W2040695574 cites W182324336 @default.
• W2040695574 cites W1964678713 @default.
• W2040695574 cites W1967825409 @default.
• W2040695574 cites W1973033067 @default.
• W2040695574 cites W1973742265 @default.
• W2040695574 cites W1978321945 @default.
• W2040695574 cites W1987151925 @default.
• W2040695574 cites W1990041102 @default.
• W2040695574 cites W1992211132 @default.
• W2040695574 cites W1992616572 @default.
• W2040695574 cites W1994716862 @default.
• W2040695574 cites W1999525220 @default.
• W2040695574 cites W2002162194 @default.
• W2040695574 cites W2002684526 @default.
• W2040695574 cites W2010453012 @default.
• W2040695574 cites W2016623911 @default.
• W2040695574 cites W2017523469 @default.
• W2040695574 cites W2019736743 @default.
• W2040695574 cites W2026331267 @default.
• W2040695574 cites W2028961192 @default.
• W2040695574 cites W2033199579 @default.
• W2040695574 cites W2036124273 @default.
• W2040695574 cites W2039215563 @default.
• W2040695574 cites W2039892303 @default.
• W2040695574 cites W2049801670 @default.
• W2040695574 cites W2051011037 @default.
• W2040695574 cites W2052819801 @default.
• W2040695574 cites W2052927456 @default.
• W2040695574 cites W2056194845 @default.
• W2040695574 cites W2056922067 @default.
• W2040695574 cites W2058026545 @default.
• W2040695574 cites W2064708316 @default.
• W2040695574 cites W2065383805 @default.
• W2040695574 cites W2073710945 @default.
• W2040695574 cites W2078489740 @default.
• W2040695574 cites W2081724296 @default.
• W2040695574 cites W2083765905 @default.
• W2040695574 cites W2083820494 @default.
• W2040695574 cites W2085172744 @default.
• W2040695574 cites W2085436867 @default.
• W2040695574 cites W2087982553 @default.
• W2040695574 cites W2100380391 @default.
• W2040695574 cites W2102953371 @default.
• W2040695574 cites W2107312575 @default.
• W2040695574 cites W2108371256 @default.
• W2040695574 cites W2125794605 @default.
• W2040695574 cites W2127273730 @default.
• W2040695574 cites W2145134032 @default.
• W2040695574 cites W2165158245 @default.
• W2040695574 cites W2331099279 @default.
• W2040695574 cites W2418942964 @default.
• W2040695574 cites W2748592855 @default.
• W2040695574 doi "https://doi.org/10.1038/sj.jcbfm.9600096" @default.
• W2040695574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15815587" @default.
• W2040695574 hasPublicationYear "2005" @default.
• W2040695574 type Work @default.
• W2040695574 sameAs 2040695574 @default.
• W2040695574 citedByCount "117" @default.
• W2040695574 countsByYear W20406955742012 @default.
• W2040695574 countsByYear W20406955742013 @default.
• W2040695574 countsByYear W20406955742014 @default.
• W2040695574 countsByYear W20406955742015 @default.
• W2040695574 countsByYear W20406955742016 @default.
• W2040695574 countsByYear W20406955742017 @default.
• W2040695574 countsByYear W20406955742018 @default.
• W2040695574 countsByYear W20406955742019 @default.
• W2040695574 countsByYear W20406955742020 @default.
• W2040695574 countsByYear W20406955742021 @default.
• W2040695574 countsByYear W20406955742022 @default.
• W2040695574 countsByYear W20406955742023 @default.
• W2040695574 crossrefType "journal-article" @default.
• W2040695574 hasAuthorship W2040695574A5003269288 @default.
• W2040695574 hasAuthorship W2040695574A5004569891 @default.
• W2040695574 hasAuthorship W2040695574A5015226179 @default.
• W2040695574 hasAuthorship W2040695574A5018202372 @default.
• W2040695574 hasAuthorship W2040695574A5030232036 @default.
• W2040695574 hasAuthorship W2040695574A5050370903 @default.
• W2040695574 hasAuthorship W2040695574A5066625527 @default.
• W2040695574 hasBestOaLocation W20406955741 @default.
• W2040695574 hasConcept C104317684 @default.
• W2040695574 hasConcept C126322002 @default.
• W2040695574 hasConcept C127561419 @default.

• next