FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040697722> ?p ?o ?g. }

• W2040697722 endingPage "1653" @default.
• W2040697722 startingPage "1649" @default.
• W2040697722 abstract "A series of andrographolide derivatives have been synthesized through enzymatic acylation reactions. Immobilized Candida antarctica lipase B (Novozym 435) was found to be a useful biocatalyst for the 35-gram scale syntheses of these acylated derivatives, and the biocatalyst displayed excellent regioselectivity and high operational stability during the transformation. The 14-substituted andrographolide derivative was the sole detectable product from each acylation reaction. The acylated andrographolides showed antibacterial activity against representative Gram-positive and Gram-negative bacteria [with minimal inhibitory concentrations (MICs) as low as 4 μg/mL], whereas andrographolide exhibited no such activity. Chain length of acyl moiety on the lactone-ring at the C-14 position plays an important role in determining the potency of the antibacterial activity. These results indicate an enzymatic modification was not only facile and green, but an effective method for the preparation of an andrographolide monoester." @default.
• W2040697722 created "2016-06-24" @default.
• W2040697722 creator A5023094543 @default.
• W2040697722 creator A5034633035 @default.
• W2040697722 creator A5041105225 @default.
• W2040697722 creator A5052045441 @default.
• W2040697722 creator A5070654618 @default.
• W2040697722 date "2011-08-01" @default.
• W2040697722 modified "2023-09-23" @default.
• W2040697722 title "Enzymatic synthesis and antibacterial activity of andrographolide derivatives" @default.
• W2040697722 cites W1549240509 @default.
• W2040697722 cites W1551309927 @default.
• W2040697722 cites W1678327261 @default.
• W2040697722 cites W184504295 @default.
• W2040697722 cites W1967492443 @default.
• W2040697722 cites W1969679774 @default.
• W2040697722 cites W1992480863 @default.
• W2040697722 cites W2004263474 @default.
• W2040697722 cites W2012804923 @default.
• W2040697722 cites W2025877107 @default.
• W2040697722 cites W2025948648 @default.
• W2040697722 cites W2039412680 @default.
• W2040697722 cites W2043141376 @default.
• W2040697722 cites W2054502083 @default.
• W2040697722 cites W2057536928 @default.
• W2040697722 cites W2064542755 @default.
• W2040697722 cites W2067924010 @default.
• W2040697722 cites W2068162310 @default.
• W2040697722 cites W2068326726 @default.
• W2040697722 cites W2078094561 @default.
• W2040697722 cites W2082730775 @default.
• W2040697722 cites W2095500933 @default.
• W2040697722 cites W2154977396 @default.
• W2040697722 cites W2168763969 @default.
• W2040697722 doi "https://doi.org/10.1016/j.procbio.2011.05.011" @default.
• W2040697722 hasPublicationYear "2011" @default.
• W2040697722 type Work @default.
• W2040697722 sameAs 2040697722 @default.
• W2040697722 citedByCount "12" @default.
• W2040697722 countsByYear W20406977222015 @default.
• W2040697722 countsByYear W20406977222017 @default.
• W2040697722 countsByYear W20406977222018 @default.
• W2040697722 countsByYear W20406977222019 @default.
• W2040697722 countsByYear W20406977222021 @default.
• W2040697722 countsByYear W20406977222022 @default.
• W2040697722 countsByYear W20406977222023 @default.
• W2040697722 crossrefType "journal-article" @default.
• W2040697722 hasAuthorship W2040697722A5023094543 @default.
• W2040697722 hasAuthorship W2040697722A5034633035 @default.
• W2040697722 hasAuthorship W2040697722A5041105225 @default.
• W2040697722 hasAuthorship W2040697722A5052045441 @default.
• W2040697722 hasAuthorship W2040697722A5070654618 @default.
• W2040697722 hasConcept C161790260 @default.
• W2040697722 hasConcept C178790620 @default.
• W2040697722 hasConcept C181199279 @default.
• W2040697722 hasConcept C185592680 @default.
• W2040697722 hasConcept C191503008 @default.
• W2040697722 hasConcept C193557335 @default.
• W2040697722 hasConcept C2776568683 @default.
• W2040697722 hasConcept C2779542420 @default.
• W2040697722 hasConcept C2779697368 @default.
• W2040697722 hasConcept C2780104969 @default.
• W2040697722 hasConcept C2781357234 @default.
• W2040697722 hasConcept C523546767 @default.
• W2040697722 hasConcept C54355233 @default.
• W2040697722 hasConcept C65024703 @default.
• W2040697722 hasConcept C71240020 @default.
• W2040697722 hasConcept C86803240 @default.
• W2040697722 hasConceptScore W2040697722C161790260 @default.
• W2040697722 hasConceptScore W2040697722C178790620 @default.
• W2040697722 hasConceptScore W2040697722C181199279 @default.
• W2040697722 hasConceptScore W2040697722C185592680 @default.
• W2040697722 hasConceptScore W2040697722C191503008 @default.
• W2040697722 hasConceptScore W2040697722C193557335 @default.
• W2040697722 hasConceptScore W2040697722C2776568683 @default.
• W2040697722 hasConceptScore W2040697722C2779542420 @default.
• W2040697722 hasConceptScore W2040697722C2779697368 @default.
• W2040697722 hasConceptScore W2040697722C2780104969 @default.
• W2040697722 hasConceptScore W2040697722C2781357234 @default.
• W2040697722 hasConceptScore W2040697722C523546767 @default.
• W2040697722 hasConceptScore W2040697722C54355233 @default.
• W2040697722 hasConceptScore W2040697722C65024703 @default.
• W2040697722 hasConceptScore W2040697722C71240020 @default.
• W2040697722 hasConceptScore W2040697722C86803240 @default.
• W2040697722 hasFunder F4320321001 @default.
• W2040697722 hasFunder F4320321106 @default.
• W2040697722 hasFunder F4320322769 @default.
• W2040697722 hasFunder F4320327518 @default.
• W2040697722 hasFunder F4320335787 @default.
• W2040697722 hasIssue "8" @default.
• W2040697722 hasLocation W20406977221 @default.
• W2040697722 hasOpenAccess W2040697722 @default.
• W2040697722 hasPrimaryLocation W20406977221 @default.
• W2040697722 hasRelatedWork W1974200402 @default.
• W2040697722 hasRelatedWork W1987204921 @default.
• W2040697722 hasRelatedWork W1989305095 @default.
• W2040697722 hasRelatedWork W1999004530 @default.
• W2040697722 hasRelatedWork W1999246737 @default.

• next