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• W2040700301 abstract "T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives substituted with arylpiperazinylalkylamines. The oxazoles were synthesized in a convenient convergent synthetic method, and biologically evaluated against α1G (CaV3.1) T-type calcium channel. Among total 41 oxazole compounds synthesized, the most active one was the compound 10-35 with an IC50 value of 0.65 μM, which is comparable with that of mibefradil." @default.
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• W2040700301 date "2010-07-01" @default.
• W2040700301 modified "2023-10-07" @default.
• W2040700301 title "Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers" @default.
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• W2040700301 doi "https://doi.org/10.1016/j.bmcl.2010.05.030" @default.
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