Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040700449> ?p ?o ?g. }
- W2040700449 endingPage "E173" @default.
- W2040700449 startingPage "E165" @default.
- W2040700449 abstract "Glucose effectiveness, the ability of glucose per se to suppress endogenous glucose production (EGP), is lost in type 2 diabetes mellitus (T2DM). Free fatty acids (FFA) may contribute to this loss of glucose effectiveness in T2DM by increasing gluconeogenesis (GNG) and impairing the response to hyperglycemia. Thus, we first examined the effects of increasing plasma FFA levels for 3, 6, or 16 h on glucose effectiveness in nondiabetic subjects. Under fixed hormonal conditions, hyperglycemia suppressed EGP by 61% in nondiabetic subjects. Raising FFA levels with Liposyn infusion for > or =3 h reduced the normal suppressive effect of glucose by one-half. Second, we hypothesized that inhibiting GNG would prevent the negative impact of FFA on glucose effectiveness. Raising plasma FFA levels increased gluconeogenesis by approximately 52% during euglycemia and blunted the suppression of EGP by hyperglycemia. Infusion of ethanol rapidly inhibited GNG and doubled the suppression of EGP by hyperglycemia, thereby restoring glucose effectiveness. In conclusion, elevated FFA levels rapidly increased GNG and impaired hepatic glucose effectiveness in nondiabetic subjects. Inhibiting GNG could have therapeutic potential in restoring the regulation of glucose production in type 2 diabetes mellitus." @default.
- W2040700449 created "2016-06-24" @default.
- W2040700449 creator A5008942207 @default.
- W2040700449 creator A5022656114 @default.
- W2040700449 creator A5039934553 @default.
- W2040700449 creator A5042024921 @default.
- W2040700449 creator A5068607180 @default.
- W2040700449 creator A5087661429 @default.
- W2040700449 date "2009-07-01" @default.
- W2040700449 modified "2023-10-10" @default.
- W2040700449 title "Inhibiting gluconeogenesis prevents fatty acid-induced increases in endogenous glucose production" @default.
- W2040700449 cites W1855569674 @default.
- W2040700449 cites W1965185106 @default.
- W2040700449 cites W1974127796 @default.
- W2040700449 cites W1978248654 @default.
- W2040700449 cites W1984033419 @default.
- W2040700449 cites W1996194590 @default.
- W2040700449 cites W2015664752 @default.
- W2040700449 cites W2022582429 @default.
- W2040700449 cites W2022584932 @default.
- W2040700449 cites W2022649084 @default.
- W2040700449 cites W2029477649 @default.
- W2040700449 cites W2033125833 @default.
- W2040700449 cites W2039246060 @default.
- W2040700449 cites W2040750115 @default.
- W2040700449 cites W2063169804 @default.
- W2040700449 cites W2070079297 @default.
- W2040700449 cites W2072656195 @default.
- W2040700449 cites W2090103643 @default.
- W2040700449 cites W2099052499 @default.
- W2040700449 cites W2099110187 @default.
- W2040700449 cites W2099129407 @default.
- W2040700449 cites W2099442609 @default.
- W2040700449 cites W2103348177 @default.
- W2040700449 cites W2104557392 @default.
- W2040700449 cites W2105897677 @default.
- W2040700449 cites W2108709856 @default.
- W2040700449 cites W2122240034 @default.
- W2040700449 cites W2126654945 @default.
- W2040700449 cites W2127564371 @default.
- W2040700449 cites W2128282444 @default.
- W2040700449 cites W2138907486 @default.
- W2040700449 cites W2139695052 @default.
- W2040700449 cites W2140653555 @default.
- W2040700449 cites W2146698746 @default.
- W2040700449 cites W2146845495 @default.
- W2040700449 cites W2153604272 @default.
- W2040700449 cites W2157513821 @default.
- W2040700449 cites W2158009122 @default.
- W2040700449 cites W2158590560 @default.
- W2040700449 cites W2158793749 @default.
- W2040700449 cites W2160384513 @default.
- W2040700449 cites W2162482242 @default.
- W2040700449 cites W2164002753 @default.
- W2040700449 cites W2164850343 @default.
- W2040700449 cites W2282684438 @default.
- W2040700449 cites W2334945609 @default.
- W2040700449 cites W2415641508 @default.
- W2040700449 cites W2418706959 @default.
- W2040700449 doi "https://doi.org/10.1152/ajpendo.00001.2009" @default.
- W2040700449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2711655" @default.
- W2040700449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19417129" @default.
- W2040700449 hasPublicationYear "2009" @default.
- W2040700449 type Work @default.
- W2040700449 sameAs 2040700449 @default.
- W2040700449 citedByCount "14" @default.
- W2040700449 countsByYear W20407004492012 @default.
- W2040700449 countsByYear W20407004492013 @default.
- W2040700449 countsByYear W20407004492014 @default.
- W2040700449 countsByYear W20407004492017 @default.
- W2040700449 countsByYear W20407004492018 @default.
- W2040700449 countsByYear W20407004492019 @default.
- W2040700449 countsByYear W20407004492021 @default.
- W2040700449 countsByYear W20407004492022 @default.
- W2040700449 crossrefType "journal-article" @default.
- W2040700449 hasAuthorship W2040700449A5008942207 @default.
- W2040700449 hasAuthorship W2040700449A5022656114 @default.
- W2040700449 hasAuthorship W2040700449A5039934553 @default.
- W2040700449 hasAuthorship W2040700449A5042024921 @default.
- W2040700449 hasAuthorship W2040700449A5068607180 @default.
- W2040700449 hasAuthorship W2040700449A5087661429 @default.
- W2040700449 hasBestOaLocation W20407004492 @default.
- W2040700449 hasConcept C126322002 @default.
- W2040700449 hasConcept C134018914 @default.
- W2040700449 hasConcept C16613235 @default.
- W2040700449 hasConcept C17093226 @default.
- W2040700449 hasConcept C185592680 @default.
- W2040700449 hasConcept C20904676 @default.
- W2040700449 hasConcept C2779306644 @default.
- W2040700449 hasConcept C543025807 @default.
- W2040700449 hasConcept C55493867 @default.
- W2040700449 hasConcept C555293320 @default.
- W2040700449 hasConcept C62231903 @default.
- W2040700449 hasConcept C71924100 @default.
- W2040700449 hasConceptScore W2040700449C126322002 @default.
- W2040700449 hasConceptScore W2040700449C134018914 @default.
- W2040700449 hasConceptScore W2040700449C16613235 @default.
- W2040700449 hasConceptScore W2040700449C17093226 @default.