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- W2040700547 abstract "<h3>Aim</h3> To investigate the expression and function of interleukin-4 receptor α (<i>IL-4Rα</i>) in human conjunctival epithelial cells (HCjECs). <h3>Methods</h3> The presence of <i>IL-4Rα</i> mRNA and protein was examined by reverse transcription (RT) PCR and immunohistology, respectively. Cell surface expression was examined by flow cytometry. The effects of interleukin (IL)-4 or IL-13 on the tyrosine phosphorylation of signal transducer and the activator of transcription 6 (STAT6) were evaluated by immunoblot analyses. The transcripts upregulated upon IL-4 stimulation were examined using GeneChip, and confirmed by quantitative RT-PCR. <h3>Results</h3> <i>IL-4Rα</i> mRNA and protein were detected in human conjunctival epithelium. <i>IL-4Rα</i> protein was expressed on the cell surface of HCjECs. IL-4 and IL-13 induced tyrosine phosphorylation of STAT6. GeneChip analysis showed that nine transcripts were upregulated more than fourfold by IL-4 stimulation in the primary HCjECs from two individuals. Quantitative RT-PCR assay confirmed the upregulation of these transcripts: <i>lecithin retinol acyltransferase (LRAT), calpain (CAPN14), tumour necrosis factor alpha-induced protein 6 (TNFAIP6), RAS guanyl-releasing protein 1 (RASGRP1), endothelin receptor type A (EDNRA), hyaluronan synthase 3 (HAS3), cathepsin C (CTSC), carbonic anhydrase II (CA2)</i> and <i>cytokine-inducible SH2-containing protein (CISH)</i>. <h3>Conclusions</h3> HCjECs expressed functioning <i>IL-4Rα</i>, and IL-4 stimulation induced the expression of several genes." @default.
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- W2040700547 date "2010-07-07" @default.
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- W2040700547 title "Expression of the interleukin-4 receptor in human conjunctival epithelial cells" @default.
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- W2040700547 doi "https://doi.org/10.1136/bjo.2009.173419" @default.
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