Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040700904> ?p ?o ?g. }
- W2040700904 endingPage "840" @default.
- W2040700904 startingPage "831" @default.
- W2040700904 abstract "Basal forebrain cholinergic neurons respond to nerve growth factor (NGF), and it has been suggested that the administration of NGF might prevent their degereration in patients with Alzheimer's disease. One major prerequisite to be fulfilled before the consideration of clinical trials of NGF in patients with Alzheimer's disease is the demonstration that human NGF affects basal forebrain cholinergic neurons in primates. In the present study, we used a recombunant human nerve growth facotr (rhNGF), which we previousl showed to be active on rat basa forebrain cholinergic neurons, in nonhuman primates with a unilateral transection of the fornix (a well-established model for the induction of retrograde degenerative changes in septal cholinergic neurons). After the lesion, one group of animals received rhNGF and a second group received vehicle solution for 2 weeks. In animals receiving vehicle, the medical septal nucleus ipsilateral to the lesion showed reductions in numbers (55°) and size of cell bodies immunoreactive for NGF receptor and choline acetyltransferase. In Sissl stains, many cells showed frduced size and basophilia. The rhNGF completely prevented alternation in the number and size of NGF receptor—and choline acetyltransferase—immunnoreactive neurons in the medical septal nucles and reversed atrophy in a subpopulation of large, basophilic medical which we have previously used in the same primate lesion paradigm. The restoration of the phenotype of injured acetylcholine-dependent memory impariments that occur in aged nonhuman primates. In concert, results of the present investigation provide critical information for the futrue use of NGF in in patients with neurological disorders that affect NGF-responsive cells in the peripherl and central nervous system." @default.
- W2040700904 created "2016-06-24" @default.
- W2040700904 creator A5009879178 @default.
- W2040700904 creator A5014387506 @default.
- W2040700904 creator A5041622936 @default.
- W2040700904 creator A5043191335 @default.
- W2040700904 creator A5054270816 @default.
- W2040700904 creator A5057156243 @default.
- W2040700904 creator A5060095356 @default.
- W2040700904 creator A5070189703 @default.
- W2040700904 date "1991-12-01" @default.
- W2040700904 modified "2023-10-07" @default.
- W2040700904 title "Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates" @default.
- W2040700904 cites W1500220781 @default.
- W2040700904 cites W1564797650 @default.
- W2040700904 cites W1609471181 @default.
- W2040700904 cites W1639832183 @default.
- W2040700904 cites W1820424262 @default.
- W2040700904 cites W1934062495 @default.
- W2040700904 cites W1969054876 @default.
- W2040700904 cites W1971369064 @default.
- W2040700904 cites W1972197544 @default.
- W2040700904 cites W1973531344 @default.
- W2040700904 cites W1977656398 @default.
- W2040700904 cites W1978817724 @default.
- W2040700904 cites W1987091321 @default.
- W2040700904 cites W1991712654 @default.
- W2040700904 cites W1998733248 @default.
- W2040700904 cites W1999385494 @default.
- W2040700904 cites W2001350842 @default.
- W2040700904 cites W2002443683 @default.
- W2040700904 cites W2003373488 @default.
- W2040700904 cites W2003522028 @default.
- W2040700904 cites W2004045063 @default.
- W2040700904 cites W2005215696 @default.
- W2040700904 cites W2005780620 @default.
- W2040700904 cites W2009804051 @default.
- W2040700904 cites W2010957694 @default.
- W2040700904 cites W2011839234 @default.
- W2040700904 cites W2015012744 @default.
- W2040700904 cites W2016254753 @default.
- W2040700904 cites W2019656577 @default.
- W2040700904 cites W2022042199 @default.
- W2040700904 cites W2022136055 @default.
- W2040700904 cites W2024238390 @default.
- W2040700904 cites W2033302933 @default.
- W2040700904 cites W2034046047 @default.
- W2040700904 cites W2037194302 @default.
- W2040700904 cites W2037338304 @default.
- W2040700904 cites W2038855320 @default.
- W2040700904 cites W2039943037 @default.
- W2040700904 cites W2045776001 @default.
- W2040700904 cites W2047945439 @default.
- W2040700904 cites W2049209075 @default.
- W2040700904 cites W2055899482 @default.
- W2040700904 cites W2061824832 @default.
- W2040700904 cites W2064659680 @default.
- W2040700904 cites W2066148497 @default.
- W2040700904 cites W2069095254 @default.
- W2040700904 cites W2070931028 @default.
- W2040700904 cites W2073695258 @default.
- W2040700904 cites W2076835610 @default.
- W2040700904 cites W2078129863 @default.
- W2040700904 cites W2083823071 @default.
- W2040700904 cites W2084076460 @default.
- W2040700904 cites W2087883041 @default.
- W2040700904 cites W2088479689 @default.
- W2040700904 cites W2089284266 @default.
- W2040700904 cites W2090858430 @default.
- W2040700904 cites W2093374391 @default.
- W2040700904 cites W2093613378 @default.
- W2040700904 cites W2117120152 @default.
- W2040700904 cites W2121543539 @default.
- W2040700904 cites W2124540184 @default.
- W2040700904 cites W2128378551 @default.
- W2040700904 cites W2131838224 @default.
- W2040700904 cites W2143158156 @default.
- W2040700904 cites W2152185487 @default.
- W2040700904 cites W2158649743 @default.
- W2040700904 cites W2166771846 @default.
- W2040700904 cites W334027006 @default.
- W2040700904 cites W4233533506 @default.
- W2040700904 cites W4254344472 @default.
- W2040700904 doi "https://doi.org/10.1002/ana.410300613" @default.
- W2040700904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1789695" @default.
- W2040700904 hasPublicationYear "1991" @default.
- W2040700904 type Work @default.
- W2040700904 sameAs 2040700904 @default.
- W2040700904 citedByCount "180" @default.
- W2040700904 countsByYear W20407009042012 @default.
- W2040700904 countsByYear W20407009042013 @default.
- W2040700904 countsByYear W20407009042014 @default.
- W2040700904 countsByYear W20407009042015 @default.
- W2040700904 countsByYear W20407009042016 @default.
- W2040700904 countsByYear W20407009042017 @default.
- W2040700904 countsByYear W20407009042018 @default.
- W2040700904 countsByYear W20407009042019 @default.
- W2040700904 countsByYear W20407009042021 @default.