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- W2040703381 abstract "The selective apoptosis-inducing activity of Amaryllidaceae alkaloids belonging to the crinane-type is reported. A mini-library of natural and synthetic crinane alkaloids was assembled. Biological screening indicated crinamine 4 and haemanthamine 9 to be potent inducers of apoptosis in tumour cells at micromolar concentrations. Structure-activity relationships demonstrated the requirement for both an alpha-C2 bridge and a free hydroxyl at the C-11 position as pharmacophoric requirements for this activity." @default.
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- W2040703381 date "2007-04-01" @default.
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- W2040703381 title "Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids" @default.
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- W2040703381 doi "https://doi.org/10.1016/j.phytochem.2007.01.006" @default.
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