FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040706178> ?p ?o ?g. }

• W2040706178 endingPage "1261" @default.
• W2040706178 startingPage "1253" @default.
• W2040706178 abstract "How oxidative metabolism modulates effects of ionizing radiation is incompletely understood. Because mitochondria participate in oxidative metabolism, we investigated the modulation of mitochondrial protein import and membrane potential (ΔΨ) in irradiated cells. Our data show that effects at low dose cannot be predicted from effects at high dose. When density-inhibited normal human fibroblasts were exposed to a toxic dose of 4 Gy, protein import into mitochondria isolated from these cells was decreased. In contrast, protein import into mitochondria isolated from low-dose–irradiated (10 cGy) cells was enhanced, suggesting that mitochondria may play a crucial role in low-dose–induced adaptive responses. At high dose, import defects were not solely due to changes in mitochondrial ΔΨ, and modulation of import was not tightly linked to the cellular capacity to repair radiation damage. Another striking observation is that in proliferating nonirradiated cells, mitochondrial protein import and ΔΨ were regulated in a cell cycle–dependent manner, being lower in S phase than in G1. Interestingly, when quiescent G0/G1 phase cells exposed to high-dose radiation were stimulated to proliferate, events associated with S phase, but not G1, significantly affected import. The strategy described here may serve as novel end points to study radiation-induced effects." @default.
• W2040706178 created "2016-06-24" @default.
• W2040706178 creator A5013841026 @default.
• W2040706178 creator A5062627219 @default.
• W2040706178 creator A5071465211 @default.
• W2040706178 creator A5084392934 @default.
• W2040706178 creator A5090488889 @default.
• W2040706178 date "2006-07-01" @default.
• W2040706178 modified "2023-10-16" @default.
• W2040706178 title "Normal Human Fibroblasts Exposed to High- or Low-Dose Ionizing Radiation: Differential Effects on Mitochondrial Protein Import and Membrane Potential" @default.
• W2040706178 cites W142202837 @default.
• W2040706178 cites W1975447309 @default.
• W2040706178 cites W1978256198 @default.
• W2040706178 cites W1992125844 @default.
• W2040706178 cites W2018940776 @default.
• W2040706178 cites W2021051229 @default.
• W2040706178 cites W2022627623 @default.
• W2040706178 cites W2023627397 @default.
• W2040706178 cites W2023990700 @default.
• W2040706178 cites W2027189348 @default.
• W2040706178 cites W2028015830 @default.
• W2040706178 cites W2029224024 @default.
• W2040706178 cites W2031573318 @default.
• W2040706178 cites W2038876723 @default.
• W2040706178 cites W2039109181 @default.
• W2040706178 cites W2039355845 @default.
• W2040706178 cites W2051567142 @default.
• W2040706178 cites W2056204961 @default.
• W2040706178 cites W2056632309 @default.
• W2040706178 cites W2061039816 @default.
• W2040706178 cites W2066252108 @default.
• W2040706178 cites W2066693401 @default.
• W2040706178 cites W2067476421 @default.
• W2040706178 cites W2068982039 @default.
• W2040706178 cites W2071111328 @default.
• W2040706178 cites W2075457116 @default.
• W2040706178 cites W2075497030 @default.
• W2040706178 cites W2076411484 @default.
• W2040706178 cites W2084491525 @default.
• W2040706178 cites W2087085768 @default.
• W2040706178 cites W2096592126 @default.
• W2040706178 cites W2101861123 @default.
• W2040706178 cites W2102355342 @default.
• W2040706178 cites W2105754268 @default.
• W2040706178 cites W2109962929 @default.
• W2040706178 cites W2111757377 @default.
• W2040706178 cites W2132826785 @default.
• W2040706178 cites W2133278360 @default.
• W2040706178 cites W2136917684 @default.
• W2040706178 cites W2164467613 @default.
• W2040706178 cites W2166274230 @default.
• W2040706178 cites W2167615157 @default.
• W2040706178 cites W2169491130 @default.
• W2040706178 cites W2336572885 @default.
• W2040706178 cites W2519275956 @default.
• W2040706178 cites W284891813 @default.
• W2040706178 cites W4243964059 @default.
• W2040706178 cites W4323915703 @default.
• W2040706178 doi "https://doi.org/10.1089/ars.2006.8.1253" @default.
• W2040706178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16910773" @default.
• W2040706178 hasPublicationYear "2006" @default.
• W2040706178 type Work @default.
• W2040706178 sameAs 2040706178 @default.
• W2040706178 citedByCount "40" @default.
• W2040706178 countsByYear W20407061782012 @default.
• W2040706178 countsByYear W20407061782013 @default.
• W2040706178 countsByYear W20407061782014 @default.
• W2040706178 countsByYear W20407061782015 @default.
• W2040706178 countsByYear W20407061782016 @default.
• W2040706178 countsByYear W20407061782017 @default.
• W2040706178 countsByYear W20407061782018 @default.
• W2040706178 countsByYear W20407061782019 @default.
• W2040706178 countsByYear W20407061782020 @default.
• W2040706178 countsByYear W20407061782021 @default.
• W2040706178 crossrefType "journal-article" @default.
• W2040706178 hasAuthorship W2040706178A5013841026 @default.
• W2040706178 hasAuthorship W2040706178A5062627219 @default.
• W2040706178 hasAuthorship W2040706178A5071465211 @default.
• W2040706178 hasAuthorship W2040706178A5084392934 @default.
• W2040706178 hasAuthorship W2040706178A5090488889 @default.
• W2040706178 hasConcept C111337013 @default.
• W2040706178 hasConcept C121332964 @default.
• W2040706178 hasConcept C12554922 @default.
• W2040706178 hasConcept C1491633281 @default.
• W2040706178 hasConcept C181911157 @default.
• W2040706178 hasConcept C18231593 @default.
• W2040706178 hasConcept C185544564 @default.
• W2040706178 hasConcept C28859421 @default.
• W2040706178 hasConcept C29537977 @default.
• W2040706178 hasConcept C55493867 @default.
• W2040706178 hasConcept C57600042 @default.
• W2040706178 hasConcept C75385678 @default.
• W2040706178 hasConcept C86803240 @default.
• W2040706178 hasConcept C95444343 @default.
• W2040706178 hasConceptScore W2040706178C111337013 @default.
• W2040706178 hasConceptScore W2040706178C121332964 @default.
• W2040706178 hasConceptScore W2040706178C12554922 @default.
• W2040706178 hasConceptScore W2040706178C1491633281 @default.

• next