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- W2040706228 abstract "1. The spontaneous [3H]-release has been measured from the isolated main pulmonary artery of the rabbit preloaded with [3H]noradrenaline in the presence of uptake blockers (cocaine, 3 × 10−5 M; corticosterone, 5 × 10−5 M). 2. The Ca-ionophore A-23187 (3 × 10−7−3 × 10−5 M) increased the outflow of [3H] by a concentration dependent manner. 3. Inhibition of Na+-pump by removal of K+ from the external medium also increased the release of labelled noradrenaline. 4. In the absence of external K+, the applied A-23187 (3 × 10−6 M; EC50) further increased the release of [3H]. 5. Reactivation of Na+-pump by readmission of K+ (5.9 mM) to the external medium abolished the [3H]-release which had previously been increased in “K+-free” solution. 6. The reactivated Na+-pump significantly inhibited the transmitter releasing action of A-23187. 7. This latter was antagonized by an increase of external Ca2+ (7.5 mM). 8. It is concluded that the reactivated Na+-pump caused re-establishment of Na+-gradient is capable to counteract the Ca-ionophore facilitated Ca2+-influx and release from internal stores, which can be antagonized by excess Ca2+." @default.
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- W2040706228 date "1989-01-01" @default.
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- W2040706228 title "A-23187 evoked transmitter release from rabbit pulmonary artery and its inhibition by reactivation of sodium-pump" @default.
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- W2040706228 doi "https://doi.org/10.1016/0306-3623(89)90190-0" @default.
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