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• W2040709455 abstract "This study was conducted to determine effect of CLA and linoleic acid (LA) on cell differentiation, cellular glycerol-3-phosphate dehydrogenase (GPDH) activity, and FA accumulation in differentiating 3T3-L1 cells (3 isomers×3 treatment periods×4 doses). The cells were cultured in 24-well plates for proliferation until confluence. Then they were treated with media containing 0, 10, 35, or 70 mg/L (0, 35, 125, or 250 mmol/L, respectively) of LA,cis9,trans11-ortrans10,cis12-CLA during early (day 0–2), intermediate and late (day 3–8), or overall (day 0–8) differentiation periods. Dexamethasone, methyl-isobutylxanthine, and insulin were supplemented to the media only for the early period to induce the differentiation. On day 8 of postconfluence the cells were harvested for Oil Red O staining, analysis of GPDH activity, and determination of the FA concentration. Cellular LA or CLA was found to accumulate in a dose-response manner, mainly during the intermediate/late period. Treatment withtrans10,cis12-CLA lowered (P<0.05) GPDH activity and the concentration of FA including palmitic acid (16∶0) and palmitoleic acid (16∶1), especially during the intermediate/late and overall periods, or whenever a high dose of 70 mg/L was applied. This also resulted in a higher (P<0.05) ratio of saturated FA to monounsaturated FA. Treatment with LA orcis9,trans11-CLA lowered cellular FA only when they applied during the early period at a dose of 70 mg/L. The results demonstrated that the inhibitory effects of CLA on differentiation, GPDH activity, and FA accumulation of 3T3-L1 cells are dependent on the isomer type, treatment period, and dose." @default.
• W2040709455 created "2016-06-24" @default.
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• W2040709455 date "2006-10-01" @default.
• W2040709455 modified "2023-10-01" @default.
• W2040709455 title "Effect of conjugated linoleic acid type, treatment period, and dosage on differentiation of 3T3 cells" @default.
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• W2040709455 doi "https://doi.org/10.1007/s11745-006-5047-0" @default.
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