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- W2040722015 abstract "RATIONALE: Exhaled nitric oxide (eNO) and exhaled breath condensate pH (EBC pH) may be useful markers of airway inflammation, a cardinal feature of asthma. The ability of inhaled corticosteroids to influence these parameters concomitantly with FEV1 and methacholine responsiveness has not been elucidated. This study examines the effects of mometasone DPI on these markers of airway inflammation in asthma. METHODS: Twelve adult steroid naïve patients with mild to moderate persistent asthma (FEV1 ≥60% predicted and PC20 methacholine <8 mg/mL) were treated with mometasone furoate DPI 400 mcg daily for 8 weeks, followed by a 4-week washout. FEV1, methacholine PC20, eNO and EBC pH were measured at baseline, during active treatment (weeks 1, 4 and 8) and during mometasone washout (post-treatment weeks 1 and 4). RESULTS: Median FEV1 at baseline was 2.99 L (89% of predicted), and was unaffected during the study. Methacholine PC20 increased by 4.1 doubling doses by treatment week 4, and remained higher throughout post-treatment week 4 (p = 0.01). Median eNO decreased from 24.6 ppb to 15.1 ppb by treatment week 1 and remained significantly lower through week 8 (p = 0.05), reverting to baseline by post-treatment week 4. Median EBC pH increased from 7.81 to 8.02 by treatment week 4, and then plateaued, although statistical significance was not achieved. CONCLUSIONS: Treatment of asthma with mometasone DPI is associated with significant improvements in methacholine responsiveness and eNO, and a trend towards increased EBC pH. These data suggest that inhaled corticosteroids affect eNO more rapidly and transiently, but airway hyperresponsiveness more slowly and persistently." @default.
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- W2040722015 date "2007-01-01" @default.
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- W2040722015 title "The Effects of Mometasone DPI on Airway Hyperresponsiveness and Markers of Airway Inflammation" @default.
- W2040722015 doi "https://doi.org/10.1016/j.jaci.2006.11.036" @default.
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