FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040726146> ?p ?o ?g. }

• W2040726146 endingPage "121" @default.
• W2040726146 startingPage "114" @default.
• W2040726146 abstract "Two new mixed ligand silver(I) complexes of formulae {[Ag(tpp)3(asp)](dmf)} (1) (aspH = o-acetylsalicylic acid and tpp = triphenylphosphine) and [Ag(tpp)2(o-Hbza)] (2) (o-HbzaH = o-hydroxy-benzoic acid) were synthesized and characterized by elemental analyses, spectroscopic techniques and X-ray crystallography at ambient conditions. Three phosphorus and one carboxylic oxygen atoms from a de-protonated aspirin ligand in complex 1 and two phosphorus and two carboxylic oxygen atoms from a chelating o-Hbza anion in complex 2 form a tetrahedral geometry around Ag(I) ions in both complexes. Complexes 1 and 2 and the silver(I) nitrate, tpp, aspNa and o-HbzaH were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS), human breast adenocarcinoma cells (MCF-7) and normal human fetal lung fibroblasts (MRC-5) cells with Thiazolyl Blue Tetrazolium Bromide (MTT) assay. For both cell lines 1 and 2 were found to be more active than cisplatin. Additionally, 1 and 2 exhibit lower activity on cell growth proliferation of MRC-5 cells. The type of LMS cell death caused by 1 and 2 were evaluated in vitro by use of flow cytometry assay. The results show that at concentrations of 1.5 and 1.9 μΜ of complex 1, 44.1% and 69.4%, respectively of LMS cells undergo programmed cell death (apoptosis). When LMS cells were treated with 1.6 and 2.3 μM of 2, LMS cells death was by 29.6% and 81.3%, respectively apoptotic. Finally, the influence of the complexes 1 and 2, upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The binding of 1 and 2 towards LOX was also investigated by Saturation Transfer Difference (STD) 1H NMR experiments." @default.
• W2040726146 created "2016-06-24" @default.
• W2040726146 creator A5003526233 @default.
• W2040726146 creator A5009553458 @default.
• W2040726146 creator A5013043945 @default.
• W2040726146 creator A5015704445 @default.
• W2040726146 creator A5015768433 @default.
• W2040726146 creator A5028880064 @default.
• W2040726146 creator A5030864083 @default.
• W2040726146 creator A5031111170 @default.
• W2040726146 creator A5047271928 @default.
• W2040726146 creator A5049533585 @default.
• W2040726146 creator A5056854458 @default.
• W2040726146 creator A5084513616 @default.
• W2040726146 date "2011-09-01" @default.
• W2040726146 modified "2023-09-26" @default.
• W2040726146 title "Synthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with triphenylphosphine and aspirin or salicylic acid" @default.
• W2040726146 cites W1972037943 @default.
• W2040726146 cites W1974609063 @default.
• W2040726146 cites W1981483353 @default.
• W2040726146 cites W1984443573 @default.
• W2040726146 cites W1985559194 @default.
• W2040726146 cites W1995385088 @default.
• W2040726146 cites W2000971285 @default.
• W2040726146 cites W2001911441 @default.
• W2040726146 cites W2005086787 @default.
• W2040726146 cites W2011342311 @default.
• W2040726146 cites W2013245417 @default.
• W2040726146 cites W2017398903 @default.
• W2040726146 cites W2019461455 @default.
• W2040726146 cites W2019542562 @default.
• W2040726146 cites W2024176341 @default.
• W2040726146 cites W2025449975 @default.
• W2040726146 cites W2029039099 @default.
• W2040726146 cites W2035104234 @default.
• W2040726146 cites W2035633424 @default.
• W2040726146 cites W2037207563 @default.
• W2040726146 cites W2041649839 @default.
• W2040726146 cites W2043855224 @default.
• W2040726146 cites W2052869703 @default.
• W2040726146 cites W2053382382 @default.
• W2040726146 cites W2059354713 @default.
• W2040726146 cites W2060668077 @default.
• W2040726146 cites W2061151008 @default.
• W2040726146 cites W2062006936 @default.
• W2040726146 cites W2063110913 @default.
• W2040726146 cites W2064240574 @default.
• W2040726146 cites W2074539671 @default.
• W2040726146 cites W2075025450 @default.
• W2040726146 cites W2076755375 @default.
• W2040726146 cites W2079513639 @default.
• W2040726146 cites W2082235753 @default.
• W2040726146 cites W2082818221 @default.
• W2040726146 cites W2083552277 @default.
• W2040726146 cites W2085781921 @default.
• W2040726146 cites W2088766474 @default.
• W2040726146 cites W2091932253 @default.
• W2040726146 cites W2102046461 @default.
• W2040726146 cites W2104553788 @default.
• W2040726146 cites W2124915682 @default.
• W2040726146 cites W2145084612 @default.
• W2040726146 cites W2151324279 @default.
• W2040726146 cites W2164759987 @default.
• W2040726146 cites W2170339479 @default.
• W2040726146 cites W243142205 @default.
• W2040726146 cites W3158212715 @default.
• W2040726146 cites W78337159 @default.
• W2040726146 doi "https://doi.org/10.1016/j.ica.2011.04.032" @default.
• W2040726146 hasPublicationYear "2011" @default.
• W2040726146 type Work @default.
• W2040726146 sameAs 2040726146 @default.
• W2040726146 citedByCount "53" @default.
• W2040726146 countsByYear W20407261462012 @default.
• W2040726146 countsByYear W20407261462013 @default.
• W2040726146 countsByYear W20407261462014 @default.
• W2040726146 countsByYear W20407261462015 @default.
• W2040726146 countsByYear W20407261462016 @default.
• W2040726146 countsByYear W20407261462017 @default.
• W2040726146 countsByYear W20407261462018 @default.
• W2040726146 countsByYear W20407261462019 @default.
• W2040726146 countsByYear W20407261462020 @default.
• W2040726146 countsByYear W20407261462021 @default.
• W2040726146 countsByYear W20407261462022 @default.
• W2040726146 crossrefType "journal-article" @default.
• W2040726146 hasAuthorship W2040726146A5003526233 @default.
• W2040726146 hasAuthorship W2040726146A5009553458 @default.
• W2040726146 hasAuthorship W2040726146A5013043945 @default.
• W2040726146 hasAuthorship W2040726146A5015704445 @default.
• W2040726146 hasAuthorship W2040726146A5015768433 @default.
• W2040726146 hasAuthorship W2040726146A5028880064 @default.
• W2040726146 hasAuthorship W2040726146A5030864083 @default.
• W2040726146 hasAuthorship W2040726146A5031111170 @default.
• W2040726146 hasAuthorship W2040726146A5047271928 @default.
• W2040726146 hasAuthorship W2040726146A5049533585 @default.
• W2040726146 hasAuthorship W2040726146A5056854458 @default.
• W2040726146 hasAuthorship W2040726146A5084513616 @default.
• W2040726146 hasConcept C116569031 @default.
• W2040726146 hasConcept C145148216 @default.

• next