FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040730084> ?p ?o ?g. }

• W2040730084 endingPage "4656" @default.
• W2040730084 startingPage "4645" @default.
• W2040730084 abstract "In our previous papers, we found that introduction of a substituent at C(2) into 1α,25-dihydroxy-19-norvitamin D3 (2a) caused dramatic changes in binding affinity for the vitamin D receptor (VDR) and in transcriptional activity compared with the parent compound. To investigate the broad biological activity of 2-substituted 19-norvitamin D analogs, we synthesized two new (20S)-2-hydroxyethylidene-19-norvitamin D derivatives (3b and 4b) and a total of 16 A-ring-modified analogs including 3b and 4b were tested for the following in vitro and in vivo biological activities: (1) affinity for the VDR, (2) transcriptional activity, (3) osteoclast formation, (4) bone calcium mobilization in rats, and (5) effects on differentiation of dendritic cells (DCs). The biological effects of the analogs were compared with those of 1α,25-dihydroxyvitamin D3 (1a) and 2MD, which is being developed for the treatment of osteoporosis. The efficacy of the (20S)-19-norvitamin D analogs with 2-hydroxyethylidene, 2-hydroxyethoxy, and 2-methyl moieties (3b, 5b, 6b, and 9b) was more than 10-fold stronger than that of 1a with respect to transcriptional activity, ability to induce osteoclast formation, and ability to inhibit CD86 expression, a marker of mature DCs, and was similar to that of 2MD. The (20S)-2β-hydroxyethoxy derivative 6b was 2 orders of magnitude more active than 1a and approximately twice as potent as 2MD in preventing CD86 production. The 2-epoxy derivatives 7 and 8 were relatively poor ligands for the VDR and exhibited activity lower than that of the natural hormone 1a." @default.
• W2040730084 created "2016-06-24" @default.
• W2040730084 creator A5014959620 @default.
• W2040730084 creator A5027108774 @default.
• W2040730084 creator A5034320377 @default.
• W2040730084 creator A5048798172 @default.
• W2040730084 creator A5060824665 @default.
• W2040730084 creator A5067929403 @default.
• W2040730084 creator A5079374747 @default.
• W2040730084 creator A5091812870 @default.
• W2040730084 date "2006-07-01" @default.
• W2040730084 modified "2023-10-18" @default.
• W2040730084 title "Analogs of 1α,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: Synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs" @default.
• W2040730084 cites W1552563052 @default.
• W2040730084 cites W1968691321 @default.
• W2040730084 cites W1970342538 @default.
• W2040730084 cites W1970366802 @default.
• W2040730084 cites W1975883008 @default.
• W2040730084 cites W2002329371 @default.
• W2040730084 cites W2002518015 @default.
• W2040730084 cites W2007852712 @default.
• W2040730084 cites W2013252828 @default.
• W2040730084 cites W2018584724 @default.
• W2040730084 cites W2018602999 @default.
• W2040730084 cites W2027946868 @default.
• W2040730084 cites W2028079886 @default.
• W2040730084 cites W2056116219 @default.
• W2040730084 cites W2060532943 @default.
• W2040730084 cites W2071873634 @default.
• W2040730084 cites W2074696981 @default.
• W2040730084 cites W2077420287 @default.
• W2040730084 cites W2077677810 @default.
• W2040730084 cites W2078409020 @default.
• W2040730084 cites W2085124463 @default.
• W2040730084 cites W2087270881 @default.
• W2040730084 cites W2093252878 @default.
• W2040730084 cites W2093300670 @default.
• W2040730084 cites W2095259916 @default.
• W2040730084 cites W2096002104 @default.
• W2040730084 cites W2101781154 @default.
• W2040730084 cites W2139922283 @default.
• W2040730084 cites W2141326395 @default.
• W2040730084 cites W2150124615 @default.
• W2040730084 cites W2154984081 @default.
• W2040730084 cites W2156684669 @default.
• W2040730084 cites W2156828729 @default.
• W2040730084 cites W2176953517 @default.
• W2040730084 cites W2413218385 @default.
• W2040730084 cites W2949262009 @default.
• W2040730084 cites W1966066872 @default.
• W2040730084 cites W1987343217 @default.
• W2040730084 doi "https://doi.org/10.1016/j.bmc.2006.02.015" @default.
• W2040730084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16513359" @default.
• W2040730084 hasPublicationYear "2006" @default.
• W2040730084 type Work @default.
• W2040730084 sameAs 2040730084 @default.
• W2040730084 citedByCount "13" @default.
• W2040730084 countsByYear W20407300842013 @default.
• W2040730084 countsByYear W20407300842017 @default.
• W2040730084 countsByYear W20407300842018 @default.
• W2040730084 countsByYear W20407300842020 @default.
• W2040730084 crossrefType "journal-article" @default.
• W2040730084 hasAuthorship W2040730084A5014959620 @default.
• W2040730084 hasAuthorship W2040730084A5027108774 @default.
• W2040730084 hasAuthorship W2040730084A5034320377 @default.
• W2040730084 hasAuthorship W2040730084A5048798172 @default.
• W2040730084 hasAuthorship W2040730084A5060824665 @default.
• W2040730084 hasAuthorship W2040730084A5067929403 @default.
• W2040730084 hasAuthorship W2040730084A5079374747 @default.
• W2040730084 hasAuthorship W2040730084A5091812870 @default.
• W2040730084 hasConcept C104317684 @default.
• W2040730084 hasConcept C116073593 @default.
• W2040730084 hasConcept C124490489 @default.
• W2040730084 hasConcept C127716648 @default.
• W2040730084 hasConcept C134018914 @default.
• W2040730084 hasConcept C148738053 @default.
• W2040730084 hasConcept C150903083 @default.
• W2040730084 hasConcept C170493617 @default.
• W2040730084 hasConcept C178790620 @default.
• W2040730084 hasConcept C179639408 @default.
• W2040730084 hasConcept C185592680 @default.
• W2040730084 hasConcept C202751555 @default.
• W2040730084 hasConcept C207001950 @default.
• W2040730084 hasConcept C2776033226 @default.
• W2040730084 hasConcept C2776079296 @default.
• W2040730084 hasConcept C2781101188 @default.
• W2040730084 hasConcept C519063684 @default.
• W2040730084 hasConcept C55493867 @default.
• W2040730084 hasConcept C57992300 @default.
• W2040730084 hasConcept C71240020 @default.
• W2040730084 hasConcept C86803240 @default.
• W2040730084 hasConcept C98274493 @default.
• W2040730084 hasConceptScore W2040730084C104317684 @default.
• W2040730084 hasConceptScore W2040730084C116073593 @default.
• W2040730084 hasConceptScore W2040730084C124490489 @default.
• W2040730084 hasConceptScore W2040730084C127716648 @default.
• W2040730084 hasConceptScore W2040730084C134018914 @default.
• W2040730084 hasConceptScore W2040730084C148738053 @default.

• next