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• W2040732030 endingPage "796" @default.
• W2040732030 startingPage "785" @default.
• W2040732030 abstract "Glycerol 3-phosphate acyltransferase (GPAT) activity and triglyceride lipase (TGL) activity were measured in homogenates from hearts perfused with adrenergic agonists and antagonists. Perfusion with adrenalin or the β-agonist isoprenaline produced an increase in TGL activity and a fall in GPAT activity. These changes could be imitated by incubation of heart homogenates with cAMP-dependent protein kinase. The α2-agonist clondine produced the opposite effect, thus it increased GPAT activity and decreased TGL activity. Methoxamine, an α1-agonist, had no effect on TGL activity but reduced GPAT activity. Continuous perfusion of the β-antagonist atenolol reduced TGL activity to half that found in controls but also reduced GPAT activity. No change was seen on continuous perfusion of α1-or α2-antagonists. Changes in GPAT activity were localized mainly in the microsomal enzyme. These changes are consistent with both enzymes being regulated via a cyclic-AMP dependent protein kinase system and via α-adrenergic mechanisms. Glycerol 3-phosphate acyltransferase (GPAT) activity and triglyceride lipase (TGL) activity were measured in homogenates from hearts perfused with adrenergic agonists and antagonists. Perfusion with adrenalin or the β-agonist isoprenaline produced an increase in TGL activity and a fall in GPAT activity. These changes could be imitated by incubation of heart homogenates with cAMP-dependent protein kinase. The α2-agonist clondine produced the opposite effect, thus it increased GPAT activity and decreased TGL activity. Methoxamine, an α1-agonist, had no effect on TGL activity but reduced GPAT activity. Continuous perfusion of the β-antagonist atenolol reduced TGL activity to half that found in controls but also reduced GPAT activity. No change was seen on continuous perfusion of α1-or α2-antagonists. Changes in GPAT activity were localized mainly in the microsomal enzyme. These changes are consistent with both enzymes being regulated via a cyclic-AMP dependent protein kinase system and via α-adrenergic mechanisms." @default.
• W2040732030 created "2016-06-24" @default.
• W2040732030 creator A5061686319 @default.
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• W2040732030 date "1985-08-01" @default.
• W2040732030 modified "2023-09-27" @default.
• W2040732030 title "The effect of adrenergic agents on the activities of glycerol 3-phosphate acyltransferase and triglyceride lipase in the isolated perfused rat heart" @default.
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• W2040732030 doi "https://doi.org/10.1016/s0022-2828(85)80040-7" @default.
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