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- W2040732572 abstract "Rad2 family nucleases, identified by sequence similarity within their catalytic domains, function in multiple pathways of DNA metabolism. Three members of the Saccharomyces cerevisiae Rad2 family, Rad2, Rad27, and exonuclease 1 (Exo1), exhibit both 5' exonuclease and flap endonuclease activities. Deletion of RAD27 results in defective Okazaki fragment maturation, DNA repair, and subsequent defects in mutation avoidance and chromosomal stability. However, strains lacking Rad27 are viable. The expression profile of EXO1 during the cell cycle is similar to that of RAD27 and other genes encoding proteins that function in DNA replication and repair, suggesting Exo1 may function as a back up nuclease for Rad27 in DNA replication. We show that overexpression of EXO1 suppresses multiple rad27 null mutation-associated phenotypes derived from DNA replication defects, including temperature sensitivity, Okazaki fragment accumulation, the rate of minichromosome loss, and an elevated mutation frequency. While generally similar findings were observed with RAD2, overexpression of RAD2, but not EXO1, suppressed the MMS sensitivity of the rad27 null mutant cells. This suggests that Rad2 can uniquely complement Rad27 in base excision repair (BER). Furthermore, Rad2 and Exo1 complemented the mutator phenotypes and cell cycle defects of rad27 mutant strains to differing extents, suggesting distinct in vivo nucleic acid substrates." @default.
- W2040732572 created "2016-06-24" @default.
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- W2040732572 date "2003-08-01" @default.
- W2040732572 modified "2023-10-16" @default.
- W2040732572 title "Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability" @default.
- W2040732572 cites W143299682 @default.
- W2040732572 cites W1506492200 @default.
- W2040732572 cites W1538766331 @default.
- W2040732572 cites W1545047192 @default.
- W2040732572 cites W1570075445 @default.
- W2040732572 cites W1575598349 @default.
- W2040732572 cites W1729887059 @default.
- W2040732572 cites W1774053018 @default.
- W2040732572 cites W184852254 @default.
- W2040732572 cites W1860417382 @default.
- W2040732572 cites W1922687004 @default.
- W2040732572 cites W1958566893 @default.
- W2040732572 cites W1966219094 @default.
- W2040732572 cites W1967209251 @default.
- W2040732572 cites W1971517620 @default.
- W2040732572 cites W1971594693 @default.
- W2040732572 cites W1981277651 @default.
- W2040732572 cites W1985882391 @default.
- W2040732572 cites W1986113777 @default.
- W2040732572 cites W1994245744 @default.
- W2040732572 cites W1995275643 @default.
- W2040732572 cites W2000965988 @default.
- W2040732572 cites W2001354035 @default.
- W2040732572 cites W2003329456 @default.
- W2040732572 cites W2005448675 @default.
- W2040732572 cites W2010544809 @default.
- W2040732572 cites W2010992218 @default.
- W2040732572 cites W2012306350 @default.
- W2040732572 cites W2013456924 @default.
- W2040732572 cites W2013735712 @default.
- W2040732572 cites W2016218438 @default.
- W2040732572 cites W2017285840 @default.
- W2040732572 cites W2020884359 @default.
- W2040732572 cites W2024939635 @default.
- W2040732572 cites W2028513756 @default.
- W2040732572 cites W2028928303 @default.
- W2040732572 cites W2031292590 @default.
- W2040732572 cites W2033676950 @default.
- W2040732572 cites W2038529419 @default.
- W2040732572 cites W2044393910 @default.
- W2040732572 cites W2046535007 @default.
- W2040732572 cites W2049812251 @default.
- W2040732572 cites W2052442016 @default.
- W2040732572 cites W2053742989 @default.
- W2040732572 cites W2055079963 @default.
- W2040732572 cites W2055348937 @default.
- W2040732572 cites W2064477710 @default.
- W2040732572 cites W2065686472 @default.
- W2040732572 cites W2069157381 @default.
- W2040732572 cites W2069926362 @default.
- W2040732572 cites W2077686584 @default.
- W2040732572 cites W2078424943 @default.
- W2040732572 cites W2081383594 @default.
- W2040732572 cites W2084712319 @default.
- W2040732572 cites W2086103125 @default.
- W2040732572 cites W2090110799 @default.
- W2040732572 cites W2090133673 @default.
- W2040732572 cites W2091512138 @default.
- W2040732572 cites W2093369849 @default.
- W2040732572 cites W2094292611 @default.
- W2040732572 cites W2103453943 @default.
- W2040732572 cites W2106837356 @default.
- W2040732572 cites W2107856790 @default.
- W2040732572 cites W2110912468 @default.
- W2040732572 cites W2111313204 @default.
- W2040732572 cites W2112035003 @default.
- W2040732572 cites W2116865857 @default.
- W2040732572 cites W2121781767 @default.
- W2040732572 cites W2123218200 @default.
- W2040732572 cites W2128481115 @default.
- W2040732572 cites W2133231925 @default.
- W2040732572 cites W2140132110 @default.
- W2040732572 cites W2140384792 @default.
- W2040732572 cites W2142485616 @default.
- W2040732572 cites W2157435389 @default.
- W2040732572 cites W2159127144 @default.
- W2040732572 cites W2281445265 @default.
- W2040732572 cites W4256590580 @default.
- W2040732572 doi "https://doi.org/10.1016/s1568-7864(03)00093-4" @default.
- W2040732572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12893088" @default.
- W2040732572 hasPublicationYear "2003" @default.
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