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• W2040735340 abstract "Transfer RNA (tRNA) genes and other RNA polymerase III transcription units are dispersed in high copy throughout nuclear genomes, and can antagonize RNA polymerase II transcription in their immediate chromosomal locus. Previous work in Saccharomyces cerevisiae found that this local silencing required subnuclear clustering of the tRNA genes near the nucleolus. Here we show that the silencing also requires nucleosome participation, though the nature of the nucleosome interaction appears distinct from other forms of transcriptional silencing. Analysis of an extensive library of histone amino acid substitutions finds a large number of residues that affect the silencing, both in the histone N-terminal tails and on the nucleosome disk surface. The residues on the disk surfaces involved are largely distinct from those affecting other regulatory phenomena. Consistent with the large number of histone residues affecting tgm silencing, survey of chromatin modification mutations shows that several enzymes known to affect nucleosome modification and positioning are also required. The enzymes include an Rpd3 deacetylase complex, Hos1 deacetylase, Glc7 phosphatase, and the RSC nucleosome remodeling activity, but not multiple other activities required for other silencing forms or boundary element function at tRNA gene loci. Models for communication between the tRNA gene transcription complexes and local chromatin are discussed." @default.
• W2040735340 created "2016-06-24" @default.
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• W2040735340 date "2013-08-01" @default.
• W2040735340 modified "2023-10-16" @default.
• W2040735340 title "Silencing near tRNA genes is nucleosome-mediated and distinct from boundary element function" @default.
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• W2040735340 doi "https://doi.org/10.1016/j.gene.2013.05.016" @default.
• W2040735340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3745993" @default.
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