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- W2040736415 endingPage "234" @default.
- W2040736415 startingPage "226" @default.
- W2040736415 abstract "Cytokines are important mediators of cardiac disease. Accumulating evidence indicates that members of the interleukin-6 family of cytokines promote cardiac hypertrophy through the activation of the Janus kinase-signal transducer and activator of transcription (Jak/STAT) pathway. Aberrant Jak/STAT signaling may promote progression from hypertrophy to heart failure. Suppressor of cytokine signaling (SOCS) proteins are underexplored, negative regulators of Jak/STAT signaling. SOCS proteins may also interact with other inflammatory pathways known to affect cardiac function. A better understanding of the therapeutic potential of these proteins may lead to the controlled progression of heart failure and the limitation of myocardial depression. This review summarizes the cardiophysiological effect of the IL-6 cytokine family, outlines the mechanistic pathway of Jak/STAT signaling, explores the regulatory role of SOCS proteins in the heart, and discusses the potential of using SOCS proteins clinically." @default.
- W2040736415 created "2016-06-24" @default.
- W2040736415 creator A5013438877 @default.
- W2040736415 creator A5013741196 @default.
- W2040736415 creator A5015279290 @default.
- W2040736415 creator A5019611695 @default.
- W2040736415 creator A5039173798 @default.
- W2040736415 creator A5072168670 @default.
- W2040736415 date "2006-09-01" @default.
- W2040736415 modified "2023-10-07" @default.
- W2040736415 title "JAK/STAT/SOCS SIGNALING CIRCUITS AND ASSOCIATED CYTOKINE-MEDIATED INFLAMMATION AND HYPERTROPHY IN THE HEART" @default.
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