FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040739900> ?p ?o ?g. }

• W2040739900 endingPage "2244" @default.
• W2040739900 startingPage "2234" @default.
• W2040739900 abstract "Protein glutathionylation is a post-translational modification that may account for a broad mechanism of redox signaling. The caspase family of cysteine proteases represents a potential target for regulation by glutathionylation. To examine this, caspase proteins, derived from HL-60 cells after activation with actinomycin D, were incubated with GSSG. Total protein glutathionylation was enhanced and caspase-3 activity was inhibited in a dose- and time-dependent manner by GSSG. Caspase inhibition was reversible by thiol-specific reducing reagents. Proteolytic activation of caspases was also affected, as the activation of procaspase-3 and procaspase-9 in HL-60 cell extracts induced by cytochrome c and dATP was inhibited by pre-incubation with GSSG. When biotin-labeled GSSG was incubated with recombinant caspase-3, biotin label was found associated with both p12 and p17 subunits of active caspase-3 by non-reducing SDS-PAGE. Caspase-3 glutathionylation was confirmed by matrix assisted laser desorption ionization (MALDI) mass spectrometric analysis of GSSG-treated recombinant caspase-3. Specific sites of glutathionylation were identified as Cys(135) of the p17 protein (the active site) and Cys(45) of the p12 protein. These results indicate that glutathionylation of caspase can occur at physiologically relevant concentrations of GSSG and results in the inhibition of caspase activation and activity." @default.
• W2040739900 created "2016-06-24" @default.
• W2040739900 creator A5008059478 @default.
• W2040739900 creator A5057237006 @default.
• W2040739900 creator A5057920756 @default.
• W2040739900 creator A5058375680 @default.
• W2040739900 date "2008-06-01" @default.
• W2040739900 modified "2023-09-26" @default.
• W2040739900 title "Inhibition of caspase-3 activity and activation by protein glutathionylation" @default.
• W2040739900 cites W1598978469 @default.
• W2040739900 cites W1614519645 @default.
• W2040739900 cites W1647523659 @default.
• W2040739900 cites W1966221856 @default.
• W2040739900 cites W1991945233 @default.
• W2040739900 cites W2002508933 @default.
• W2040739900 cites W2002870564 @default.
• W2040739900 cites W2003055213 @default.
• W2040739900 cites W2006120070 @default.
• W2040739900 cites W2007064404 @default.
• W2040739900 cites W2011342890 @default.
• W2040739900 cites W2018603950 @default.
• W2040739900 cites W2020538411 @default.
• W2040739900 cites W2020671984 @default.
• W2040739900 cites W2024758557 @default.
• W2040739900 cites W2025038110 @default.
• W2040739900 cites W2028096273 @default.
• W2040739900 cites W2055636186 @default.
• W2040739900 cites W2056174699 @default.
• W2040739900 cites W2057511360 @default.
• W2040739900 cites W2057521823 @default.
• W2040739900 cites W2079792068 @default.
• W2040739900 cites W2081145901 @default.
• W2040739900 cites W2085601435 @default.
• W2040739900 cites W2091886434 @default.
• W2040739900 cites W2092055824 @default.
• W2040739900 cites W2112768034 @default.
• W2040739900 cites W2129793754 @default.
• W2040739900 cites W2137552764 @default.
• W2040739900 cites W2139305993 @default.
• W2040739900 cites W2142544974 @default.
• W2040739900 cites W2143082454 @default.
• W2040739900 cites W2149967205 @default.
• W2040739900 cites W2159840889 @default.
• W2040739900 cites W2164760296 @default.
• W2040739900 cites W2169950408 @default.
• W2040739900 cites W4242581870 @default.
• W2040739900 doi "https://doi.org/10.1016/j.bcp.2008.02.026" @default.
• W2040739900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2453044" @default.
• W2040739900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18395187" @default.
• W2040739900 hasPublicationYear "2008" @default.
• W2040739900 type Work @default.
• W2040739900 sameAs 2040739900 @default.
• W2040739900 citedByCount "107" @default.
• W2040739900 countsByYear W20407399002012 @default.
• W2040739900 countsByYear W20407399002013 @default.
• W2040739900 countsByYear W20407399002014 @default.
• W2040739900 countsByYear W20407399002015 @default.
• W2040739900 countsByYear W20407399002016 @default.
• W2040739900 countsByYear W20407399002017 @default.
• W2040739900 countsByYear W20407399002018 @default.
• W2040739900 countsByYear W20407399002019 @default.
• W2040739900 countsByYear W20407399002020 @default.
• W2040739900 countsByYear W20407399002021 @default.
• W2040739900 countsByYear W20407399002022 @default.
• W2040739900 countsByYear W20407399002023 @default.
• W2040739900 crossrefType "journal-article" @default.
• W2040739900 hasAuthorship W2040739900A5008059478 @default.
• W2040739900 hasAuthorship W2040739900A5057237006 @default.
• W2040739900 hasAuthorship W2040739900A5057920756 @default.
• W2040739900 hasAuthorship W2040739900A5058375680 @default.
• W2040739900 hasBestOaLocation W20407399002 @default.
• W2040739900 hasConcept C104317684 @default.
• W2040739900 hasConcept C12519072 @default.
• W2040739900 hasConcept C153911025 @default.
• W2040739900 hasConcept C181199279 @default.
• W2040739900 hasConcept C182220744 @default.
• W2040739900 hasConcept C185592680 @default.
• W2040739900 hasConcept C190283241 @default.
• W2040739900 hasConcept C2775998712 @default.
• W2040739900 hasConcept C2779201268 @default.
• W2040739900 hasConcept C29311851 @default.
• W2040739900 hasConcept C31573885 @default.
• W2040739900 hasConcept C40767141 @default.
• W2040739900 hasConcept C55493867 @default.
• W2040739900 hasConcept C86803240 @default.
• W2040739900 hasConcept C98424977 @default.
• W2040739900 hasConceptScore W2040739900C104317684 @default.
• W2040739900 hasConceptScore W2040739900C12519072 @default.
• W2040739900 hasConceptScore W2040739900C153911025 @default.
• W2040739900 hasConceptScore W2040739900C181199279 @default.
• W2040739900 hasConceptScore W2040739900C182220744 @default.
• W2040739900 hasConceptScore W2040739900C185592680 @default.
• W2040739900 hasConceptScore W2040739900C190283241 @default.
• W2040739900 hasConceptScore W2040739900C2775998712 @default.
• W2040739900 hasConceptScore W2040739900C2779201268 @default.
• W2040739900 hasConceptScore W2040739900C29311851 @default.
• W2040739900 hasConceptScore W2040739900C31573885 @default.
• W2040739900 hasConceptScore W2040739900C40767141 @default.

• next