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- W2040744087 abstract "The DNA intercalating, ellipticine analog drug, 5,11-dimethyl-5H-indolo[2,3-b]quinoline, is able to stabilize in vitro the topoisomerase II-DNA cleavable complex and to induce DNA breaks in BPV I episome in rat fibroblasts. Cytotoxicity studies with DC3F cells resistant to ellipticine strongly suggest that topoisomerase II is a cellular target involved in the mechanism of cytotoxic action of this carboline derivative." @default.
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- W2040744087 date "1992-12-01" @default.
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- W2040744087 title "A carboline derivative as a novel mammalian DNA topoisomerase II targeting agent" @default.
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- W2040744087 doi "https://doi.org/10.1016/0006-2952(92)90341-f" @default.
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