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• W2040755747 abstract "Purpose To describe the radiation-induced acute rectal toxicity (ART) using a modified Lyman-Kutcher-Burman normal tissue complication probability model and parameters set, taking into account the overall treatment time. Methods and Materials A total of 160 patients underwent three-dimensional conformal radiotherapy to the prostate and seminal vesicles and were randomized to receive 80 Gy in 40 fractions within 8 weeks (Group A) or 62 Gy in 20 fractions within 5 weeks, 4 d/wk (Group B). An additional 52 patients (Group C) underwent intensity-modulated radiotherapy with a hypofractionation schedule consisting of 56 Gy, delivered in 16 fractions (4/wk) of 3.5 Gy. Patients were followed for ART weekly during treatment. The overall treatment time, rectal dose–volume histograms, and ART status, defined as Radiation Therapy Oncology Group Grade 2 or greater gastrointestinal toxicity, were used to determine the modified Lyman-Kutcher-Burman model parameters. The m and n values were obtained from the cohort, and the tolerance doses for 50% complication probability for uniform irradiation [TD50(1)k] were obtained for each fractionation schedule indicated with k. Results Of 212 patients treated with localized prostate radiotherapy, 65 developed Grade for ≥1 week during treatment. The m and n value was 0.17 and 0.08, respectively. The TD50(1)k parameter was 79, 62.5, and 53 Gy, respectively for Group A, B, and C. Conclusion The optimized modified Lyman-Kutcher-Burman normal tissue complication probability model allowed us to describe the ART data from conventional and hypofractionated regimens, using the dose–volume histograms and overall treatment time. This model could prove useful in designing hypofractionation schedules to reduce the incidence of ART. To describe the radiation-induced acute rectal toxicity (ART) using a modified Lyman-Kutcher-Burman normal tissue complication probability model and parameters set, taking into account the overall treatment time. A total of 160 patients underwent three-dimensional conformal radiotherapy to the prostate and seminal vesicles and were randomized to receive 80 Gy in 40 fractions within 8 weeks (Group A) or 62 Gy in 20 fractions within 5 weeks, 4 d/wk (Group B). An additional 52 patients (Group C) underwent intensity-modulated radiotherapy with a hypofractionation schedule consisting of 56 Gy, delivered in 16 fractions (4/wk) of 3.5 Gy. Patients were followed for ART weekly during treatment. The overall treatment time, rectal dose–volume histograms, and ART status, defined as Radiation Therapy Oncology Group Grade 2 or greater gastrointestinal toxicity, were used to determine the modified Lyman-Kutcher-Burman model parameters. The m and n values were obtained from the cohort, and the tolerance doses for 50% complication probability for uniform irradiation [TD50(1)k] were obtained for each fractionation schedule indicated with k. Of 212 patients treated with localized prostate radiotherapy, 65 developed Grade for ≥1 week during treatment. The m and n value was 0.17 and 0.08, respectively. The TD50(1)k parameter was 79, 62.5, and 53 Gy, respectively for Group A, B, and C. The optimized modified Lyman-Kutcher-Burman normal tissue complication probability model allowed us to describe the ART data from conventional and hypofractionated regimens, using the dose–volume histograms and overall treatment time. This model could prove useful in designing hypofractionation schedules to reduce the incidence of ART." @default.
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• W2040755747 date "2009-04-01" @default.
• W2040755747 modified "2023-10-18" @default.
• W2040755747 title "Mathematical Model for Evaluating Incidence of Acute Rectal Toxicity During Conventional or Hypofractionated Radiotherapy Courses for Prostate Cancer" @default.
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• W2040755747 doi "https://doi.org/10.1016/j.ijrobp.2008.07.024" @default.
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