FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040765285> ?p ?o ?g. }

• W2040765285 endingPage "161" @default.
• W2040765285 startingPage "152" @default.
• W2040765285 abstract "Summary The major therapy for haemophilia is plasma derived or recombinant clotting factors which are evolving steadily to increase potency, stability and half‐life. Research in the area of haemophilia therapeutics, however, is not restricted only to modifications in the recombinant products, but alternate therapeutic strategies are being developed which are in different phases of experimental and clinical trials. This chapter reviews the diverse molecular innovations which are being developed for alternate therapeutic approaches in haemophilia. The data is mainly extracted from the literature and the Conference abstracts. Some of the novel therapeutic approaches include inhibition of anticoagulant pathway factors (activated protein C, antithrombin, tissue factor pathway inhibitor) by monoclonal antibodies, peptide inhibitors, DNA or RNA aptamers, use of variant coagulation factors (factor Xa, factor Va) which are more resistant to inactivation or enzymatically more active and antibody‐mediated therapy including a humanized anti‐factor IX a/X bispecific antibody mimicking factor VIII . Other approaches include nonsense mutation suppression, induction of prothrombotic microparticles by P‐selectin‐immunoglobulin chimeras, suppression of fibrinolytic potential either by antifibrinolytics or by the use of mutant molecules of fibrinolytic inhibitors. Few products are proposed as ‘stand alone’ treatment for haemophilia, while a few can be used as adjuvant therapies to recombinant factors with an aim to reduce the amount of factor intake. All efforts are underway to produce an alternate, novel drug for haemophilia which will have an increased half‐life, subcutaneously injectable, non‐immunogenic and effective both in the presence and absence of inhibitors." @default.
• W2040765285 created "2016-06-24" @default.
• W2040765285 creator A5031782697 @default.
• W2040765285 creator A5080193162 @default.
• W2040765285 date "2014-12-18" @default.
• W2040765285 modified "2023-09-22" @default.
• W2040765285 title "Novel therapeutic approaches for haemophilia" @default.
• W2040765285 cites W1595352439 @default.
• W2040765285 cites W1819294471 @default.
• W2040765285 cites W1958739183 @default.
• W2040765285 cites W1964530118 @default.
• W2040765285 cites W1964630716 @default.
• W2040765285 cites W1968924601 @default.
• W2040765285 cites W1969594434 @default.
• W2040765285 cites W1971882295 @default.
• W2040765285 cites W1973207117 @default.
• W2040765285 cites W1977023032 @default.
• W2040765285 cites W1978559805 @default.
• W2040765285 cites W1985562310 @default.
• W2040765285 cites W1986747192 @default.
• W2040765285 cites W1992288140 @default.
• W2040765285 cites W1994326519 @default.
• W2040765285 cites W1997424807 @default.
• W2040765285 cites W2002041775 @default.
• W2040765285 cites W2006874399 @default.
• W2040765285 cites W2009338993 @default.
• W2040765285 cites W2012931305 @default.
• W2040765285 cites W2015087800 @default.
• W2040765285 cites W2015362487 @default.
• W2040765285 cites W2019932049 @default.
• W2040765285 cites W2020394577 @default.
• W2040765285 cites W2026336161 @default.
• W2040765285 cites W2032093921 @default.
• W2040765285 cites W2034649063 @default.
• W2040765285 cites W2035405944 @default.
• W2040765285 cites W2039533429 @default.
• W2040765285 cites W2044920882 @default.
• W2040765285 cites W2048599158 @default.
• W2040765285 cites W2054975076 @default.
• W2040765285 cites W2056485344 @default.
• W2040765285 cites W205940566 @default.
• W2040765285 cites W2059758932 @default.
• W2040765285 cites W2059843712 @default.
• W2040765285 cites W2060366140 @default.
• W2040765285 cites W2064125431 @default.
• W2040765285 cites W2064929711 @default.
• W2040765285 cites W2067253061 @default.
• W2040765285 cites W2067691677 @default.
• W2040765285 cites W2068858247 @default.
• W2040765285 cites W2072548941 @default.
• W2040765285 cites W2081472554 @default.
• W2040765285 cites W2083552707 @default.
• W2040765285 cites W2083945745 @default.
• W2040765285 cites W2085071162 @default.
• W2040765285 cites W2086294372 @default.
• W2040765285 cites W2089536721 @default.
• W2040765285 cites W2090982204 @default.
• W2040765285 cites W2097386544 @default.
• W2040765285 cites W2100851236 @default.
• W2040765285 cites W2108803513 @default.
• W2040765285 cites W2108913566 @default.
• W2040765285 cites W2110565049 @default.
• W2040765285 cites W2130322126 @default.
• W2040765285 cites W2141439233 @default.
• W2040765285 cites W2141465303 @default.
• W2040765285 cites W2148152038 @default.
• W2040765285 cites W2149767219 @default.
• W2040765285 cites W2155673319 @default.
• W2040765285 cites W2158558422 @default.
• W2040765285 cites W2267087160 @default.
• W2040765285 cites W2276861322 @default.
• W2040765285 cites W2402818220 @default.
• W2040765285 cites W2484083978 @default.
• W2040765285 cites W2516382296 @default.
• W2040765285 cites W2521263619 @default.
• W2040765285 cites W2564562448 @default.
• W2040765285 cites W4318900601 @default.
• W2040765285 cites W98360032 @default.
• W2040765285 doi "https://doi.org/10.1111/hae.12615" @default.
• W2040765285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25521966" @default.
• W2040765285 hasPublicationYear "2014" @default.
• W2040765285 type Work @default.
• W2040765285 sameAs 2040765285 @default.
• W2040765285 citedByCount "16" @default.
• W2040765285 countsByYear W20407652852015 @default.
• W2040765285 countsByYear W20407652852016 @default.
• W2040765285 countsByYear W20407652852017 @default.
• W2040765285 countsByYear W20407652852018 @default.
• W2040765285 countsByYear W20407652852023 @default.
• W2040765285 crossrefType "journal-article" @default.
• W2040765285 hasAuthorship W2040765285A5031782697 @default.
• W2040765285 hasAuthorship W2040765285A5080193162 @default.
• W2040765285 hasConcept C104317684 @default.
• W2040765285 hasConcept C126322002 @default.
• W2040765285 hasConcept C141071460 @default.
• W2040765285 hasConcept C159654299 @default.
• W2040765285 hasConcept C203014093 @default.
• W2040765285 hasConcept C2777081929 @default.

• next