FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040766672> ?p ?o ?g. }

• W2040766672 endingPage "139" @default.
• W2040766672 startingPage "131" @default.
• W2040766672 abstract "Infections caused by Aspergillus species are increasing in importance, especially among immunocompromised hosts. The objective of this study was to evaluate the efficacy of combination treatment consisting of the polyene amphotericin B (AMB) or amphotericin B-intralipid admixture (AMB-IL) and the echinocandin caspofungin (CAS) in experimental murine systemic aspergillosis. Inhibition of synthesis of a major component of the fungal cell wall and an effect on the cell membrane, by combining echinocandin and a polyene, may result in a synergistic interaction in vitro and in vivo against Aspergillus fumigatus.ICR mice were immunosuppressed by intraperitoneal (ip) administration of cyclophosphamide (CY). Three days post-CY administration the mice were inoculated intravenously (iv) with A. fumigatus conidia. Infection and treatment were evaluated during an observation period of 30 days in terms of mortality (survival rate and mean survival time) and morbidity (quantitative determination of fungal burden, histopathology, and detection of serum galactomannan).The data showed that combined CAS and AMB or AMB-IL treatment increased the survival of the mice (up to 69.2%) as compared to those treated with each agent alone (44.4, 40.7 and 50%, respectively), and prolonged their mean survival time to 22.5 days. These combinations also resulted in reduction of fungal burden in organs, and decrease in serum galactomannan.The successful results obtained in the experimental animal model of this study may possibly open the way to more effective management of aspergillosis in humans." @default.
• W2040766672 created "2016-06-24" @default.
• W2040766672 creator A5047099947 @default.
• W2040766672 creator A5062442206 @default.
• W2040766672 creator A5082531797 @default.
• W2040766672 date "2006-08-01" @default.
• W2040766672 modified "2023-09-27" @default.
• W2040766672 title "Efficacy of amphotericin B or amphotericin B–intralipid in combination with caspofungin against experimental aspergillosis" @default.
• W2040766672 cites W1575274098 @default.
• W2040766672 cites W1833207062 @default.
• W2040766672 cites W1979793180 @default.
• W2040766672 cites W1987415607 @default.
• W2040766672 cites W1990121552 @default.
• W2040766672 cites W1992853157 @default.
• W2040766672 cites W1995255591 @default.
• W2040766672 cites W2037970310 @default.
• W2040766672 cites W2048103841 @default.
• W2040766672 cites W2048902256 @default.
• W2040766672 cites W2056222459 @default.
• W2040766672 cites W2060521506 @default.
• W2040766672 cites W2069050364 @default.
• W2040766672 cites W2072576088 @default.
• W2040766672 cites W2098017193 @default.
• W2040766672 cites W2099769947 @default.
• W2040766672 cites W2108719290 @default.
• W2040766672 cites W2115265168 @default.
• W2040766672 cites W2121243320 @default.
• W2040766672 cites W2130173410 @default.
• W2040766672 cites W2136911714 @default.
• W2040766672 cites W2143363666 @default.
• W2040766672 cites W2153400187 @default.
• W2040766672 cites W2153911335 @default.
• W2040766672 cites W2156261111 @default.
• W2040766672 cites W2160143310 @default.
• W2040766672 cites W2338427714 @default.
• W2040766672 cites W2099075973 @default.
• W2040766672 doi "https://doi.org/10.1016/j.jinf.2005.10.015" @default.
• W2040766672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16360214" @default.
• W2040766672 hasPublicationYear "2006" @default.
• W2040766672 type Work @default.
• W2040766672 sameAs 2040766672 @default.
• W2040766672 citedByCount "45" @default.
• W2040766672 countsByYear W20407666722012 @default.
• W2040766672 countsByYear W20407666722013 @default.
• W2040766672 countsByYear W20407666722014 @default.
• W2040766672 countsByYear W20407666722015 @default.
• W2040766672 countsByYear W20407666722016 @default.
• W2040766672 countsByYear W20407666722017 @default.
• W2040766672 countsByYear W20407666722019 @default.
• W2040766672 countsByYear W20407666722023 @default.
• W2040766672 crossrefType "journal-article" @default.
• W2040766672 hasAuthorship W2040766672A5047099947 @default.
• W2040766672 hasAuthorship W2040766672A5062442206 @default.
• W2040766672 hasAuthorship W2040766672A5082531797 @default.
• W2040766672 hasConcept C150903083 @default.
• W2040766672 hasConcept C203014093 @default.
• W2040766672 hasConcept C207001950 @default.
• W2040766672 hasConcept C2776391196 @default.
• W2040766672 hasConcept C2779175654 @default.
• W2040766672 hasConcept C2779320740 @default.
• W2040766672 hasConcept C2779548794 @default.
• W2040766672 hasConcept C2779629538 @default.
• W2040766672 hasConcept C2779787849 @default.
• W2040766672 hasConcept C2780402444 @default.
• W2040766672 hasConcept C2780651595 @default.
• W2040766672 hasConcept C2780782397 @default.
• W2040766672 hasConcept C2780908437 @default.
• W2040766672 hasConcept C71924100 @default.
• W2040766672 hasConcept C86803240 @default.
• W2040766672 hasConcept C89423630 @default.
• W2040766672 hasConcept C98274493 @default.
• W2040766672 hasConceptScore W2040766672C150903083 @default.
• W2040766672 hasConceptScore W2040766672C203014093 @default.
• W2040766672 hasConceptScore W2040766672C207001950 @default.
• W2040766672 hasConceptScore W2040766672C2776391196 @default.
• W2040766672 hasConceptScore W2040766672C2779175654 @default.
• W2040766672 hasConceptScore W2040766672C2779320740 @default.
• W2040766672 hasConceptScore W2040766672C2779548794 @default.
• W2040766672 hasConceptScore W2040766672C2779629538 @default.
• W2040766672 hasConceptScore W2040766672C2779787849 @default.
• W2040766672 hasConceptScore W2040766672C2780402444 @default.
• W2040766672 hasConceptScore W2040766672C2780651595 @default.
• W2040766672 hasConceptScore W2040766672C2780782397 @default.
• W2040766672 hasConceptScore W2040766672C2780908437 @default.
• W2040766672 hasConceptScore W2040766672C71924100 @default.
• W2040766672 hasConceptScore W2040766672C86803240 @default.
• W2040766672 hasConceptScore W2040766672C89423630 @default.
• W2040766672 hasConceptScore W2040766672C98274493 @default.
• W2040766672 hasIssue "2" @default.
• W2040766672 hasLocation W20407666721 @default.
• W2040766672 hasLocation W20407666722 @default.
• W2040766672 hasOpenAccess W2040766672 @default.
• W2040766672 hasPrimaryLocation W20407666721 @default.
• W2040766672 hasRelatedWork W2001970376 @default.
• W2040766672 hasRelatedWork W2040766672 @default.
• W2040766672 hasRelatedWork W2091172229 @default.
• W2040766672 hasRelatedWork W2114439810 @default.
• W2040766672 hasRelatedWork W2137961342 @default.

• next