Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040770112> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2040770112 endingPage "194" @default.
- W2040770112 startingPage "187" @default.
- W2040770112 abstract "Abstract: Exposure of human neuroblastoma SK-N-MC cells to 100 µM dopamine (DA) for 72 h caused 70% loss of immunodetectable membrane-bound levels of the α-subunit of Gs. The loss in Gsα was accompanied by reduced (64.3 ± 0.35% of control values) NaF-mediated stimulation of adenylyl cyclase and was independent of accumulated cyclic AMP (cAMP) levels, because neither forskolin nor dibutyryl cAMP treatment of cells mimicked the DA-induced effects. The reduction in Gsα content was manifest at the transcriptional level; Gsα mRNA levels were attenuated to 56.5 ± 10% of control values after a 24-h treatment of cells with 100 µM DA. The concentration of DA required to produce the half-maximal decrease of Gsα mRNA content was 20 nM, similar to the high-affinity binding value (8.5 nM) of DA to D1 sites. Gsα mRNA levels were also attenuated (52 ± 3.5% of control values) by the D1-selective agonist SKF R-38393 but not by forskolin or dibutyryl cAMP. Attenuation of Gsα mRNA levels by agonists was blocked by the D1-selective antagonist SCH 23390. Stimulation of adenylyl cyclase-inhibitory DA receptors, which are coexpressed in these cells, failed to down-regulate Gsα mRNA, indicating that regulation of Gsα mRNA expression occurs specifically through chronic stimulation of D1 DA receptors." @default.
- W2040770112 created "2016-06-24" @default.
- W2040770112 creator A5026807389 @default.
- W2040770112 creator A5059704901 @default.
- W2040770112 date "2002-11-18" @default.
- W2040770112 modified "2023-09-24" @default.
- W2040770112 title "A Novel Regulation of Expression of the α-Subunit of the G Stimulatory Protein by Dopamine via D1 Dopamine Receptors" @default.
- W2040770112 doi "https://doi.org/10.1046/j.1471-4159.1997.68010187.x" @default.
- W2040770112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8978725" @default.
- W2040770112 hasPublicationYear "2002" @default.
- W2040770112 type Work @default.
- W2040770112 sameAs 2040770112 @default.
- W2040770112 citedByCount "12" @default.
- W2040770112 countsByYear W20407701122013 @default.
- W2040770112 crossrefType "journal-article" @default.
- W2040770112 hasAuthorship W2040770112A5026807389 @default.
- W2040770112 hasAuthorship W2040770112A5059704901 @default.
- W2040770112 hasConcept C104317684 @default.
- W2040770112 hasConcept C105580179 @default.
- W2040770112 hasConcept C115466790 @default.
- W2040770112 hasConcept C120069818 @default.
- W2040770112 hasConcept C126322002 @default.
- W2040770112 hasConcept C134018914 @default.
- W2040770112 hasConcept C170493617 @default.
- W2040770112 hasConcept C176303035 @default.
- W2040770112 hasConcept C185592680 @default.
- W2040770112 hasConcept C24998067 @default.
- W2040770112 hasConcept C2751546 @default.
- W2040770112 hasConcept C2778938600 @default.
- W2040770112 hasConcept C2779178603 @default.
- W2040770112 hasConcept C2779276759 @default.
- W2040770112 hasConcept C2779917531 @default.
- W2040770112 hasConcept C513476851 @default.
- W2040770112 hasConcept C55493867 @default.
- W2040770112 hasConcept C71924100 @default.
- W2040770112 hasConcept C80631254 @default.
- W2040770112 hasConcept C86803240 @default.
- W2040770112 hasConceptScore W2040770112C104317684 @default.
- W2040770112 hasConceptScore W2040770112C105580179 @default.
- W2040770112 hasConceptScore W2040770112C115466790 @default.
- W2040770112 hasConceptScore W2040770112C120069818 @default.
- W2040770112 hasConceptScore W2040770112C126322002 @default.
- W2040770112 hasConceptScore W2040770112C134018914 @default.
- W2040770112 hasConceptScore W2040770112C170493617 @default.
- W2040770112 hasConceptScore W2040770112C176303035 @default.
- W2040770112 hasConceptScore W2040770112C185592680 @default.
- W2040770112 hasConceptScore W2040770112C24998067 @default.
- W2040770112 hasConceptScore W2040770112C2751546 @default.
- W2040770112 hasConceptScore W2040770112C2778938600 @default.
- W2040770112 hasConceptScore W2040770112C2779178603 @default.
- W2040770112 hasConceptScore W2040770112C2779276759 @default.
- W2040770112 hasConceptScore W2040770112C2779917531 @default.
- W2040770112 hasConceptScore W2040770112C513476851 @default.
- W2040770112 hasConceptScore W2040770112C55493867 @default.
- W2040770112 hasConceptScore W2040770112C71924100 @default.
- W2040770112 hasConceptScore W2040770112C80631254 @default.
- W2040770112 hasConceptScore W2040770112C86803240 @default.
- W2040770112 hasIssue "1" @default.
- W2040770112 hasLocation W20407701121 @default.
- W2040770112 hasLocation W20407701122 @default.
- W2040770112 hasOpenAccess W2040770112 @default.
- W2040770112 hasPrimaryLocation W20407701121 @default.
- W2040770112 hasRelatedWork W1993214280 @default.
- W2040770112 hasRelatedWork W2027969846 @default.
- W2040770112 hasRelatedWork W2040770112 @default.
- W2040770112 hasRelatedWork W2045452477 @default.
- W2040770112 hasRelatedWork W2057948342 @default.
- W2040770112 hasRelatedWork W2075331483 @default.
- W2040770112 hasRelatedWork W2079521776 @default.
- W2040770112 hasRelatedWork W2087585854 @default.
- W2040770112 hasRelatedWork W2150623384 @default.
- W2040770112 hasRelatedWork W3015329054 @default.
- W2040770112 hasVolume "68" @default.
- W2040770112 isParatext "false" @default.
- W2040770112 isRetracted "false" @default.
- W2040770112 magId "2040770112" @default.
- W2040770112 workType "article" @default.