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• W2040771492 abstract "Synthesis and secretion of immunomodulatory proteins, such as cytokines and chemokines, controls the inflammatory response within pancreatic islets. When this inflammation does not resolve, destruction of pancreatic islet β-cells leads to diabetes mellitus. Production of the soluble mediators of inflammation, such as TNF-α and IL-1β, from resident and invading immune cells, as well as directly from islet β-cells, is also associated with suboptimal islet transplantation outcomes. In this study, we found that IL-1β induces rapid increases in TNF-α mRNA in rat and human islets and the 832/13 clonal β-cell line. The surge in transcription of the TNF-α gene required the inhibitor of kappa B kinase beta (IκKβ), the p65 subunit of the NF-κB and a signal-specific recruitment of RNA polymerase II to the gene promoter. Of note was the increased intracellular production of TNF-α protein in a manner consistent with mRNA accumulation in response to IL-1β, but no detectable secretion of TNF-α into the media. Additionally, TNF-α specifically induces expression of CD11b, but not CD11c, on neutrophils, which could contribute to the inflammatory milieu and diabetes progression. We conclude that activation of the NF-κB pathway in pancreatic β-cells leads to rapid intracellular production of the pro-inflammatory TNF-α protein through a combination of specific histone covalent modifications and NF-κB signaling pathways." @default.
• W2040771492 created "2016-06-24" @default.
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• W2040771492 date "2014-11-01" @default.
• W2040771492 modified "2023-09-25" @default.
• W2040771492 title "Transcription of the gene encoding TNF-α is increased by IL-1β in rat and human islets and β-cell lines" @default.
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• W2040771492 doi "https://doi.org/10.1016/j.molimm.2014.05.019" @default.
• W2040771492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4157113" @default.
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