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• W2040772756 abstract "When bound to cell surfaces, certain lectins such as concanavalin A induce a drop in the average diffusion coefficients (D) of a number of cell surface molecules. To find whether such anchorage modulation occurs naturally, D of surface antigens on different cell and tissue types were measured by fluorescence photobleaching recovery. Values for cells of the same tissue origin under different conditions of growth and association - in tissues, in small aggregates, and as isolated cells - varied by less than twofold when polyspecific monovalent antibodies to cell surface antigens were used, a range much less than the sixfold decrease in D observed after lectin-induced anchorage modulation. Thus, if reversible modulation of the diffusion rate is used naturally as a means of cell signaling, it must involve only a few kinds of surface receptors not detected by the antibodies used in this study. In certain tissues, however, a significant proportion of cells showed no apparent receptor mobility. This all or none modulation of lateral diffusion may reflect relatively long-lasting alterations in the states of a single cell type or differentiation among the cells of the particular tissue." @default.
• W2040772756 created "2016-06-24" @default.
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• W2040772756 date "1981-08-21" @default.
• W2040772756 modified "2023-09-23" @default.
• W2040772756 title "Lateral Diffusion of Surface Molecules in Animal Cells and Tissues" @default.
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• W2040772756 doi "https://doi.org/10.1126/science.7196087" @default.
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