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- W2040773208 abstract "The effects of forskolin and 1-Methyl-3-isobutyl-xanthine on thrombopathic platelet function and cyclic AMP accumulation were examined. The concentration of forskolin required to inhibit gamma-thrombin- induced platelet aggregation and secretion by 50% was significantly lower for thrombopathic than for normal platelets. This inhibition was accompanied by a marked elevation of cyclic AMP. 1-Methyl-3-isobutyl-xanthine, alone or in combination with forskolin, augmented both the cyclic AMP accumulation and the inhibition of platelet function. These results demonstrate that cyclic AMP metabolism is abnormal in thrombopathic platelets and imply that cyclic AMP-phosphodiesterase activity is impaired." @default.
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- W2040773208 date "1986-10-01" @default.
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- W2040773208 title "Impaired cAMP metabolism associated with abnormal function of thrombopathic canine platelets" @default.
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- W2040773208 doi "https://doi.org/10.1016/0006-291x(86)90773-4" @default.
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