FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040773852> ?p ?o ?g. }

• W2040773852 endingPage "1321" @default.
• W2040773852 startingPage "1311" @default.
• W2040773852 abstract "S100A4 is a Ca-binding protein participating in regulation of cell growth, survival, and motility. Here we studied the role of S100A4 protein in sex hormone-regulated bone formation. Bone mineral density in the trabecular and cortical compartments was evaluated in female S100A4 knockout (KO), in matched wild-type (WT) counterparts, and in WT mice treated with lentiviral small hairpin RNA construct inhibiting the S100A4 gene transcription or with a nontargeting construct, by peripheral quantitative computed tomography. The effect of sex hormones on bone was measured 5 weeks after ovariectomy (OVX) and/or dehydroepiadrosterone treatment. S100A4KO had an excessive trabecular and cortical bone formation compared with the age- and sex-matched WT mice. S100A4KO had an increased periosteal circumference (P = .001), cortical thickness (P = .056), and cortical area (P = .003), which predicted 20% higher bone strength in S100A4KO (P = .013). WT mice treated with small hairpin RNA-S100A4 showed an increase of the cortical bone parameters in a fashion identical with S100A4KO mice, indicating the key role of S100A4 in the changed bone formation. S100A4KO mice had higher serum levels of osteocalcin and a higher number of osteocalcin-positive osteoblasts under the periosteum. OVX-S100A4 resulted in the loss of the cortical bone supported by high CTX-I levels, whereas no such changes were observed in OVX-WT mice. S100A4KO mice resisted the dehydroepiadrosterone -induced bone formation observed in the WT counterparts. Our study indicates that S100A4 is a regulator of bone formation, which inhibits bone excess in the estrogen-sufficient mice and prevents the cortical bone loss in the estrogen-deprived mice." @default.
• W2040773852 created "2016-06-24" @default.
• W2040773852 creator A5028731430 @default.
• W2040773852 creator A5040483846 @default.
• W2040773852 creator A5062435845 @default.
• W2040773852 creator A5066540554 @default.
• W2040773852 creator A5075679467 @default.
• W2040773852 date "2013-08-01" @default.
• W2040773852 modified "2023-09-26" @default.
• W2040773852 title "Metastasin S100A4 Is a Mediator of Sex Hormone-Dependent Formation of the Cortical Bone" @default.
• W2040773852 cites W109896574 @default.
• W2040773852 cites W1964239649 @default.
• W2040773852 cites W1966148058 @default.
• W2040773852 cites W1966976625 @default.
• W2040773852 cites W1970785643 @default.
• W2040773852 cites W1972183638 @default.
• W2040773852 cites W1975071038 @default.
• W2040773852 cites W1984809608 @default.
• W2040773852 cites W1990038965 @default.
• W2040773852 cites W1997807118 @default.
• W2040773852 cites W1999865803 @default.
• W2040773852 cites W2014057800 @default.
• W2040773852 cites W2015418522 @default.
• W2040773852 cites W2019009327 @default.
• W2040773852 cites W2023965832 @default.
• W2040773852 cites W2028921328 @default.
• W2040773852 cites W2033187542 @default.
• W2040773852 cites W2053773140 @default.
• W2040773852 cites W2065085361 @default.
• W2040773852 cites W2069245164 @default.
• W2040773852 cites W2080207867 @default.
• W2040773852 cites W2087286553 @default.
• W2040773852 cites W2087407206 @default.
• W2040773852 cites W2091688245 @default.
• W2040773852 cites W2093252878 @default.
• W2040773852 cites W2094420610 @default.
• W2040773852 cites W2096381386 @default.
• W2040773852 cites W2103062902 @default.
• W2040773852 cites W2109301975 @default.
• W2040773852 cites W2115611328 @default.
• W2040773852 cites W2121575062 @default.
• W2040773852 cites W2124160476 @default.
• W2040773852 cites W2124998345 @default.
• W2040773852 cites W2126518515 @default.
• W2040773852 cites W2134565188 @default.
• W2040773852 cites W2137339494 @default.
• W2040773852 cites W2143697387 @default.
• W2040773852 cites W2149809213 @default.
• W2040773852 cites W2151530210 @default.
• W2040773852 cites W2152382332 @default.
• W2040773852 cites W2155366512 @default.
• W2040773852 cites W2156116786 @default.
• W2040773852 cites W2156872018 @default.
• W2040773852 cites W2158788164 @default.
• W2040773852 cites W2160287478 @default.
• W2040773852 cites W2170291048 @default.
• W2040773852 cites W2171434323 @default.
• W2040773852 cites W2290326436 @default.
• W2040773852 doi "https://doi.org/10.1210/me.2012-1398" @default.
• W2040773852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5427947" @default.
• W2040773852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23798573" @default.
• W2040773852 hasPublicationYear "2013" @default.
• W2040773852 type Work @default.
• W2040773852 sameAs 2040773852 @default.
• W2040773852 citedByCount "9" @default.
• W2040773852 countsByYear W20407738522014 @default.
• W2040773852 countsByYear W20407738522015 @default.
• W2040773852 countsByYear W20407738522018 @default.
• W2040773852 countsByYear W20407738522019 @default.
• W2040773852 countsByYear W20407738522020 @default.
• W2040773852 countsByYear W20407738522021 @default.
• W2040773852 countsByYear W20407738522023 @default.
• W2040773852 crossrefType "journal-article" @default.
• W2040773852 hasAuthorship W2040773852A5028731430 @default.
• W2040773852 hasAuthorship W2040773852A5040483846 @default.
• W2040773852 hasAuthorship W2040773852A5062435845 @default.
• W2040773852 hasAuthorship W2040773852A5066540554 @default.
• W2040773852 hasAuthorship W2040773852A5075679467 @default.
• W2040773852 hasBestOaLocation W20407738521 @default.
• W2040773852 hasConcept C105702510 @default.
• W2040773852 hasConcept C126322002 @default.
• W2040773852 hasConcept C131075544 @default.
• W2040773852 hasConcept C134018914 @default.
• W2040773852 hasConcept C160160445 @default.
• W2040773852 hasConcept C170033053 @default.
• W2040773852 hasConcept C181199279 @default.
• W2040773852 hasConcept C202751555 @default.
• W2040773852 hasConcept C2776541429 @default.
• W2040773852 hasConcept C2776886416 @default.
• W2040773852 hasConcept C2777164284 @default.
• W2040773852 hasConcept C2777425516 @default.
• W2040773852 hasConcept C2777674748 @default.
• W2040773852 hasConcept C2778260815 @default.
• W2040773852 hasConcept C2781451080 @default.
• W2040773852 hasConcept C55493867 @default.
• W2040773852 hasConcept C71924100 @default.
• W2040773852 hasConcept C86803240 @default.
• W2040773852 hasConceptScore W2040773852C105702510 @default.

• next